Investigation of anti-arthritic activity (in-vitro models) of Hibiscus hispidissimus Griffith
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 1
Abstract
Aim of the experiment: The present study was designed to investigate the anti-arthritic potential of the plant Hibiscus hispidissimus. Materials and Methods: The aerial parts of the plant was collected, dried and extracted (maceration) with ethanol. Preliminary phytochemical studies were carried out. All the in-vitro models i.e. inhibition of protein denaturation, membrane stabilization and proteinase inhibition were carried out with standard reference drug diclofenac sodium. Result: Dose dependent and significant (p<0.05) anti arthritic activity in in-vitro models were found. Conclusion: The results reveal promising anti arthritic potential of the plant. However further pharmacological investigation using isolated active ingredients can be carried out to confirm its efficacy and mechanism of action.
Authors and Affiliations
Shilpa K, Nimmy Chacko, Prerana Shetty, Sandhya Savithri A
Keywords
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