Anti-tussive activity of Shwasakuthara Rasa a Herbomineral formulation prepared with and without Kajjali (Black Sulphide of Mercury) in SO2 induced cough in Swiss albino mice
Journal Title: The Journal of Phytopharmacology - Year 2016, Vol 5, Issue 2
Abstract
Introduction: Kajjali is considered as the base in maximum Rasa Yogas (Herbo-mineral formulations). Shwasakuthara Rasa (SKR) is a well-known herbo-mineral formulation indicated in different kinds of Shwasa (respiratory diseases) and Kasa (cough) having Kajjali as a base ingredient. The present study is to evaluate the acute toxicity and anti-tussive activity of SKR one prepared with Kajjali (SKR1) and another without Kajjali (SKR2) in sulphur dioxide induced cough model in albino mice. Materials and Methods: Acute toxicity study was carried as per the OECD 425 guideline in wistar female rats. Anti-tussive activity was carried out against sulphur dioxide-induced cough reflex in mice. Results: Animals did not manifest any signs of toxicity and mortality at the dose of 2000mg/kg body weight, orally. Both test drugs (32.5 mg/kg, po) showed significant reduction in cough reflexes compared with control. SKR1 showed pronounced anti-tussive activity followed by SKR2 when compared to control group. Conclusion: The presence of Kajjali in the formulation is safe on acute administration and further enhances anti-tussive activity of the formulation may be due to increasing bioavailability of Ayurvedic formulation.
Authors and Affiliations
Bhagyalakshmi B R, Galib R, Mukesh Nariya, Prajapati PK
Keywords
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