Gastric and duodenal antiulcer effects of aqueous bark extract of Dialium guineense Wild. (Fabaceae) and the possible mechanisms in laboratory models
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 5
Abstract
The plant Dialium guineense (DAG) has been claimed by local users, to be effective in the treatment of peptic ulcers, especially, when taken as an aqueous decoction. The present study assessed the antiulcer activity of the plant, as well as explored the possible mechanisms of action of the herbal drug, aside identifying some of the various phytoconstituents, which could be responsible for its antiulcer activity. Different ulcerogens (ethanol 99.9 %, indomethacin 50 mg/kg, cysteamine 400 mg/kg, glacial acetic acid) and the pylorus ligation-induced ulcers were used to induce acute and chronic ulcers, with doses of 100, 300 and 750 mg/kg DAG and the standard drugs relative to each model, while assessing drug activity through ulcer scoring and comparing it with both the negative and positive controls. The extract, which has an LD50 of 1584.89 mg/kg when administered intraperitoneally, recorded a significant (p<0.05) antiulcer effect in all the models used in the study. Similarly, in the pylorus-ligated group, DAG compared effectively with atropine (1 mg/kg) and ranitidine (100 mg/kg), the standard antagonists of the secretagogues- carbachol and histamine employed in the study. The herbal drug produced a significant reduction in gastric juice volume, as well as in the free and the total acidity. The results suggest that DAG possesses a significant antiulcer property through cytoprotective and antisecretory actions, and it could be projected that the presence of secondary metabolites such as tannins, saponins and flavonoids could be responsible for its ulcer protective and healing property. The study therefore validates the folkloric use of DAG in the treatment of peptic ulcer.
Authors and Affiliations
Esther Oluwatoyin Agbaje, Yewa Peace Doe
Keywords
Related Articles
- EP ID EP49653
- DOI -
- Views 181
- Downloads 0
Evaluation of hypoglycemic effect of ethanolic seed extracts of Citrullus lanatus
Background: Diabetes is one of the most serious, chronic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It is becoming the third “killer” of the health of...
Antiinflammatory, analgesic and antipyretic effects of dichloromethane stem bark extract of Acacia mellifera
The present study was designed to assess the in vivo antiinflammatory, analgesic and antipyretic effect of the dichloromethane stem bark extract of Acacia mellifera on experimental animal model at three different dose...
Withania somnifera attenuates nicotine induced locomotor sensitization and withdrawal symptoms in mice
Objective: To investigate the effect of withania somnifera extract (WSE) on nicotine mediated reinforcement effect and withdrawal symptoms which attributed for the addiction liabilities of nicotine. Methods: In Swiss a...
Antipyretic and antioxidant activities of Eleucine indica
Eleucine indica is a medicinal plant used by the Ibibios of southern Nigeria in the treatment of malaria fever and also as a tonic. This study was to evaluate the antipyretic activities of the ethanol extract and the a...
Effect of Centella asiatica against anti-tuberculosis drugs-induced hepatotoxicity: Involvement of mitochondria and oxidative stress
The liver is an integral organ in the body and plays a vital role for the metabolism of endogenous and exogenous agents. Drug-induced liver toxicity is one of most common cause of liver injury. It accounts for approxim...