Investigation of Hypoglycemic Effect 4-(2--Hydroxyethyl)phenol Compounds Is from Iraqi an Prosopis Juliflora Pods On Level of Glucose Blood of Alloxan - Induced Diabetes Rabbits
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 10, Issue 9
Abstract
Prosopis juliflora is herbal plant traditionally used in different countries to treat diabetes .In present study the chemicals  of Prosopis juliflora pods were specified by GC-MS ,NMR ,IR and TLC techniques which identified the many chemicals family compounds .extraction percentage of 4-(2’-Hydroxyethyl)phenol  compound was    (2.532 % ) . Alloxan –induced diabetic rabbits were prepared in present study after injecting the experimental rabbit with three dose of alloxan  (I.V).Hyperglycemic  rabbits were divided to tow groups. First group was administration orally with 0.3 g/kg of  Phenolic  compound (treatment group)) and second group was administrated orally with normal saline  (control group) . the lowest level of glucose was observed in alloxan –induced diabetic rabbits that administrated with phenolic compound  and the significant decreasing was observed after 4hrs of administration  at ( P<0.001). ). Its can be concluded from the current study the phenolic compound from Prosopis juliflora pods is very good for reduce  glucose blood of hyperglycemic  rabbits the  4-(2’-Hydroxyethyl)phenol compound    isolated  was  purified and identified using TLC ,NMR ,GC-MS,IR techniques.Therefor this compound can be used safely to treat diabetes mellitus.
Authors and Affiliations
Jamal Harbi Hussien Alsaadi, Abbas Dawwas Mattar Al-Maliki
Keywords
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- EP ID EP652791
- DOI 10.24297/jac.v10i9.879
- Views 135
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