Investigation of the positive effects of silymarin on valproic acid-induced liver damage in rats
Journal Title: UNKNOWN - Year 2019, Vol 5, Issue 1
Abstract
Purpose: In this study; We aimed to investigate the possible hepatoprotective effects of silymarin against hepatic damage in valproic acid-induced rats using histological and biochemical evaluations. Method: Experimental procedures were performed on 21 male Sprague Dawley rats. Rats were seperated into three groups: group 1, control; group 2, valproic acid; group 3, valproic acid + silymarin. The groups were administered 500 mg/kg/day valproic acidand 100 mg/kg/daysilymarin for 14 days, except control group. Results: Silymarin treatment decreased the levels of serumgamma glutamyl transferase, alanine amino transferase, aspartate aminotransferase and increreased serum albumin levelssignificantly (p<0.05). In addition, increased amount of malondialdehyde and decreased levels of glutathione with valproic acid were significantly suppressed by silymarin in liver tissue (p<0.05).The combination of silymarinwith valproic acid reduced loss of body weight in the present study. Histologically, the extent of liver damage was remarkably lower in the valproic acid+silymarin group (p<0.005). When the valproic acid + silymarin group compared to the valproic acid group; it was determined that antioxidant activity was increased, oxidative stress. Conclusion: This study revealed that the liver injury induced by valproic acid was attenuated with silymarin administration. Silymarincan protect rat liver against valproic acid induced injury by its anti-oxidative effect, and might be useful for reducing the severity of liver injury.
Authors and Affiliations
İbrahim AKTAŞ
Keywords
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