INVESTIGATION OF THE RELATIONSHIP OF COMPUTED TOMOGRAPHY HISTOGRAM ANALYSIS WITH SURVIVAL TIME AND LOCAL CONTROL TIME IN HEAD AND NECK SQUAMOUS CELL CARCINOMA TREATED WITH CHEMORADIOTHERAPY
Journal Title: Kocatepe Medical Journal - Year 2023, Vol 24, Issue 2
Abstract
OBJECTIVE: This study aimed to evaluate the association between computed tomography (CT) histogram analysis and overall survival and local control in head and neck squamous cell carcinoma (HNSCC) treated with chemoradiotherapy. MATERIAL AND METHODS: Data archive and CT images from the ‘HNSCC’ study, which is publicly available on ‘The Cancer Imaging Archive’ website, were used in this study. Patients with known Human papilloma virus (HPV) status of the tumor who were treated with concurrent chemoradiotherapy and had pretreatment contrast-enhanced neck CT examination with a slice thickness of 1.3 mm were included. Histogram analysis was performed on 112 tumors and 98 lymphadenopathies. Tumor and lymphadenopathy boundaries, including cystic and necrotic areas, were manually drawn from a single axial CT slice where the lesion size was the largest. Then, histogram parameters [mean, variance, skewness, kurtosis, 1st percentile (P), 10th P, 50th P, 90th P, 99th P] were calculated from the corresponding areas. Kaplan Meier method and univariate and multivariate Cox proportional hazard models were used to examine the association between CT histogram parameters and overall survival and local control. RESULTS: 95 males and 17 females were included in this study (mean age 59±9.54 years). Mean overall survival was 69.3 months, local control duration was 68.4 months, and the five-year survival rate was 84%. Multivariate Cox proportional hazard model adjusted for age, sex, smoking, HPV status, and primary tumor T (tumor), N (lymph node), and TNM (tumor-lymph node-metastasis) stages showed that mean, 50th P, 90th P, 99th P values of the lymphadenopathy were independent predictors of overall survival, and mean, 1st P, 10th P values of the tumor were independent predictors of local control. CONCLUSIONS: CT histogram analysis could serve as a pretreatment noninvasive biomarker for predicting overall survival and local control in HNSCC treated with chemoradiotherapy.
Authors and Affiliations
Sevtap ARSLAN Yasin SARIKAYA
Keywords
Related Articles
- EP ID EP722626
- DOI https://doi.org/10.18229/kocatepetip.1034928
- Views 18
- Downloads 0
ANALYSIS OF THE RELATIONSHIP BETWEEN CHROMOSOME POLYMOPHISMS AND INFERTILITY
OBJECTIVE: It was aimed to compare the group consisting 391 cases (178 females, 213 males) diagnosed with infertility and performed karyotype analysis, and a control group consisting of 40 couples in terms of the chromos...
PROSPECTIVE ANALYSIS OF MUSCLE-SKELETON SYSTEM COMPLAINTS ENCOUNTERED IN PREGNANCY AND POSTPARTUM PERIOD
OBJECTIVE: Bone-joint disorders are frequently encountered in mothers during pregnancy and postpartum period. Prevention, treatment and management of these complaints should be planned specifically for pregnant women. Th...
COMPARISON OF EMERGENCY SURGERY OF CROHN'S DISEASE IN PATIENTS WITH AND WITHOUT PRIOR DIAGNOSIS OF CROHN
OBJECTIVE: Although there are many new developments in the treatment of Crohn's disease (CD), the need for surgical treatment is required between 70% and 90% at various stages of the disease. Surgical treatment indicatio...
EVALUATION OF PATIENTS PRESENTING WITH THE COMPLAINT OF HEMOPTYSIS
OBJECTIVE: Hemoptysis is the expectoration of blood originating from the pulmonary or bronchial vascular system. Hemoptysis is most commonly seen in lung cancers, tuberculosis and bronchiectasis. Also it can be an import...
COMPARISON OF REFERRALS TO A UNIVERSITY CHILD AND ADOLESCENT PSYCHIATRY OUT-PATIENT UNIT BEFORE AND DURING THE COVID-19 PANDEMIC
OBJECTIVE: It’s essential to carefully assess and define the effects of illness conception and precautions related to COVID-19 pandemic, in addition to it’s physical effects, on children followed-up in psychiatry clinics...