Investigation of Uric Acid and Cystatin C on Low-Carbohydrate Diet (LCD)
Journal Title: Diabetes Research – Open Journal - Year 2017, Vol 3, Issue 2
Abstract
Background: As to nutritional therapy, continuous discussions were observed concerning calorie restriction (CR) and low-carbohydrate diet (LCD). Authors and colleagues have applied LCD for lots of diabetic patients and reported the detail relationship with ketone bodies and Morbus (M) value. Methods: Ninety-three patients with type 2 diabetes mellitus (T2DM) were considered as subjects in the study, among which 41 were male and 52 were female, 58.3±13.2 years old on average, 60 years old in median. Methods were as follows: 1) patients were admitted and provided formular diet, which included CR diet (60% carbohydrates, 1400 kcal/day) on day 1-2, and LCD (12% carbohydrate, 1400 kcal/day) on day 3-14; 2) several biomarkers on fasting were measured on day 2, 4 and 14; 3) daily profile of blood glucose were done on day 2 and day 4. Results: According to the M-value, subjects were classified into 4 groups, which were less than 25, 26-100, 101-250, more than 251, and number was 24, 24, 24, 21, respectively. The average HbA1c in 4 groups were 6.6%, 7.4%, 8.5% and 9.5% respectively. The median M-values decreased from day 2 to 4, which were 10.4 to 9.1, 53.5 to 7.7, 150 to 19.1 and 438 to 87, respectively. The average uric acid in each group revealed significant increase from day 2 to day 14. There were significant correlation between uric acid increment and creatinine increment, and among creatinine, creatinine clearance (CCr) and Cystatin C. Conclusion: LCD showed efficacy for glucose variability with significant decrease in glucose and M-value. Renal study showed increase of serum uric acid. In addition to correlations of Cystatin C and biomarkers, current results would be from some dehydrated state and/or relative decrease of total calorie intake. These findings would become the fundamental data of efficacy of LCD and its physiological influences for renal function.
Authors and Affiliations
Hiroshi Bando
Keywords
Related Articles
- EP ID EP550223
- DOI 10.17140/DROJ-3-133
- Views 117
- Downloads 0
Are BCAAs Mere Biomarkers of Diabetes?
Branched-chain amino acids (BCAAs; ie. leucine, isoleucine, and valine) are essential amino acids we need to ingest through our diet.While circulating BCAA levels were first found to be elevated in obese individuals back...
Population-Based Strategy for Preventing Diabetes and its Complications
A recent report from the American College of Physicians (ACP) should cause a paradigm change for the treatment of diabetic patients.1 The main purpose of diabetes therapy is the prevention of complications.2 The endpoi...
Investigation of Uric Acid and Cystatin C on Low-Carbohydrate Diet (LCD)
Background: As to nutritional therapy, continuous discussions were observed concerning calorie restriction (CR) and low-carbohydrate diet (LCD). Authors and colleagues have applied LCD for lots of diabetic patients and r...
Basic Ketone Engine and Booster Glucose Engine for Energy Production
Recently, hyperketonemia induced by fasting or ketogenic diet calls attention because of the possibilities for various clinical applications. Animal species comparisons and biochemical data show that all fetuses can deve...
Associations of Waist-to-Height Ratio withVarious Emotional and Irregular Eating, andMaking Environment to Promote Eating in Japanese Adults: The Saku Cohort Study
Objective: The waist-to-height ratio (WHtR) has started gaining attention as a measure of abdominal obesity. While the associations between various eating behaviors and high BMI or obesity or overweight determined by BMI...