Iron and the liver – a novel approach to the old problem
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 1
Abstract
Increased body iron storage leads to various, clinically relevant complications. Concepts of iron metabolism disturbance has evolved over last decades and historical theory of hemochromatosis being monogenic, intestinal and high penetrance disease has been fundamentally changed. Recent findings clearly showed that this condition is in fact multigenic, liver related and has a low penetrance. Discovery of hepcidin played a critical role in understanding of iron metabolism. As a result, disturbance of iron metabolism can now be divided into: (1) genetic iron overload including haemochromatosis related to mutations in the HFE gene, hemojuvelin, transferrin receptor type 2 and hepcidin genes, (2) non-hameochromatotic conditions related to mutation in the ferroportin, ceruloplasmin, transferrin and di-metal transporter 1 genes, and (3) acquired iron-overload syndromes. However, the regulation of hepcidin action remains to be fully understood also in the context of environmental and genetic modifiers of iron burden. The aim of this review is to provide an update on the pathogenesis and therapeutic aspects of impaired iron metabolism.
Authors and Affiliations
Joanna Raszeja-Wyszomirska, Piotr Milkiewicz
Keywords
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