Is Intraarticular Administration of Tranexamic Acid Better than Its Intravenous Administration in Reducing Blood loss after total Knee Arthroplasty?
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 11
Abstract
ontext: Intravenous (IV) tranexamic acid (TXA) is a goodpotent agent in controlling postoperative blood loss following total knee arthroplasty (TKA). Recently, intraarticular usage of this agent has also shown good results. Aims: Comparison of postoperative blood loss between IV(intravenous) and topical administration of TXA tranexamic acid in TKAs(total knee arthroplasty) Materials and Design: Eighty-six TKAs on knees were included in ourstudy. Randomization was done, so that in our study 40 TKA received 1 g of IV TXA, while 46 had underwent intraarticular administration of 1 gm of TXA. Subjects and Methods: We have compared the postoperative blood loss by calculating the difference in pre- and postop hemoglobin and the need for blood transfusion for patients .The functional assessment was done on basis of Western Ontario McMaster Osteo-Arthritis Index (WOMAC) scores and complications like postoperative infection, oozing from wound site and thromboembolic manifestations. Results: The blood loss was significantly less in the intraarticular administration group as compared to the IV injection group. The total blood loss, blood transfusion, and drain output was also less but the difference was not significant. The functional assessment (WOMAC) scores were equivocal and so were the complications including thromboembolic manifestations (two cases each of deep vein thrombosis (DVT) .There was no cases of pulmonary embolism (PE)). Conclusion: The intraarticular administration of TXA to prevent postoperative bleeding or blood loss in TKA is a safe and effective alternative to its intravenous usage.
Authors and Affiliations
Dr Mehamil K. V
Keywords
Related Articles
- EP ID EP523466
- DOI -
- Views 59
- Downloads 0
Spinal anesthesia at L2-3 vs L3-4 levels: comparison of onset of block, maximum level of block and hemodynamic response in obstetric patients undergoing caesarian section
Background and Aims: Today intrathecal anaesthesia is used for almost any procedure below umbilicus. The present study evaluated Spinal anesthesia at L2-3 vs L3-4 levels with comparison of onset of block, maximum level o...
Uterine Electrical Activity During First Stage of Labor
Palpation tecnique still used today, studies have shown that this technique is uneffective for measuring uterine contractions during labor. Electromyogram (EMG) with surface electrodes is a non-invasive tool that can be...
Comparison between Combination of Spinal and General Anesthesia with Plain General Anesthesia in Patients Undergoing Laparoscopic Gynaecological Surgeries
Aim and Objective: The present study was undertaken to compare the combination of spinal (SA) and general anesthesia (GA) with plain general anesthesia (GA) in terms of heamodynamic parameters, requirement of rescue anal...
Giant Cell Tumour of the Distal Ulna: A Case Report
Introduction: Giant cell tumour (GCT) in distal ulna is a rare site. GCT is a benign and locally aggressive tumour. Generally occurs in adults between the ages of 20 and 40 years. This is very unusual, with a reported in...
Evaluation of the adverse drug reaction information for the multidrug resistant tuberculosis (MDR-TB) patients in a TB hospital in Mumbai (India)
Introduction: Second line drug treatment regimens for Drug Resistant Tuberculosis (DRTB) are lengthy and toxic, presenting a challenge to patient compliance. Information Education Communication (ICE) material usually lac...