Is low serum 25(OH) vitamin D a risk factor for childhood pneumonias?
Journal Title: Dicle Tıp Dergisi - Year 2012, Vol 39, Issue 4
Abstract
Objectives: 25(OH) vitamin D receptors have been described in immune system cells, particularly those producing antibodies, such as T and B lymphocytes, macrophages and dendritic cells. This study aimed to investigate serum 25(OH) vitamin D levels in children hospitalized with pneumonia. Materials and methods: Eighty patients, 40 male and 40 female, aged between 1 and 15 months and hospitalized with a diagnosis of pneumonia were included. Forty healthy children, 19 female and 21 male, comprised the control group. Patient and control groups were compared in terms of serum 25(OH) vitamin D, calcium, alkaline phosphatase, parathyroid hormone and CD4/CD8 ratio and bone mineral densitometry. Patients’ fever, coughing, pulmonary auscultation findings, time to amelioration of radiological appearances and duration of treatment were also compared. Results: 25(OH) vitamin D levels were below 20 ng/mL in 54.7% (n=43) of the patient group and 25% (n=10) of the controls (p<0.001). Fever began improving in 2.5 days in the cases with low serum 25(OH) vitamin D levels, coughing in 5.3 days, pulmonary auscultation findings in 8.4 days and radiological findings in 20.6 days. Average time to healing in cases with serum 25(OH) vitamin D levels <20 ng/mL was 13.7 days, compared to 7.2 days in cases with serum 25(OH) vitamin D levels >20 ng/mL. Conclusions: Low 25(OH) vitamin D levels may be a risk factor for childhood pneumonias. Serum 25(OH) vitamin D levels should be investigated in cases of lower respiratory tract infection. We think that if Serum 25(OH) vitamin levels <20 ng/mL supplemental 25(OH) vitamin D should be given. Key words: Vitamin D, pneumonia, immune system
Authors and Affiliations
Tuba Ünal, Behzat Özkan, Atilla Çayır, Avni Kaya, Zerrin Orbak
Karotis intima-media kalınlığının koroner arter hastalık şiddetini belirleyen Gensini skoru ile ilişkisi
Amaç: Bu çalışmada karotis intima media kalınlığının (KİMK) koroner arter hastalarında (KAH) hastalığın ciddiyetini göstermede objektif bir bulgu olan Gensini skoru ile ilişkisini araştırmayı amaçladık. Yöntemler: Göğü...
Guillain-Barre sendromunda klinik ve demografik özellikler
Amaç: Guillain-Barre Sendrom'lu (GBS) hastaların epidemiyolojik, klinik, laboratuvar ve elektrofizyolojik bulguları değerlendirilmesi amaçladık. Yöntemler: Çalışmaya Güneydoğu Anadolu bölge nüfusunu temsil ettiği düşün...
A Case of Primary Pulmonary Lymphoma
Primary pulmonary lymphoma, which is constitutes only 0,5% of all lung tumors, is a rare tumor arising from intrapulmonary lymphatics. Due to presentation with mass and consolidation, many diseases, require to be consi...
Jinekolojik kitlelerde pelvik manyetik rezonans görüntüleme
Amaç: Bu çalışmanın amacı adneksiyel ve uterin kitle olgularında pelvik manyetik rezonans görüntüleme (MRG) tetkikinin tanısal etkinliğini ve ultrasonografi (US)‘ye katkısını değerlendirmektir. Gereç ve yöntem: Jinekolo...
Coronary Artery Disease Frequency in Asymptomatic Low Ejection Fraction Patients
Objective: In asymptomatic and incidentally detected low ejection fraction patients, performing a coronary angiography (CAG) is not recommended routinely. But the prognosis for patients with ischemic etiology remains...