IS THE INSULIN RESISTANCE A REGULATOR ON THE LEVELS OF INSULIN AND TESTOSTERONE IN SEMINAL PLASMA IN MEN WITH METABOLIC SYNDROME.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 5
Abstract
Introduction: The morbidly weight gain is associated with multiple hormonal interactions with potential negative effect on male fertility. It is not clearly understood if visceral adiposity or Insulin Resistance (IR), or both together, is the key mediator for decreasing the testosterone (T) synthesis and activity in men with metabolic syndrome (MS). The aim: of the study is to establish the influence of IR on the semen levels of Insulin (Ins) and as well as the semen concentration, motility and morphology in men with MS. Material and methods: A pilot prospective study was done among obese men with IR without knowing fertile problems on age between 20-40 years. According to their BMI the participants were divided into three groups: first group (G1), of non-obese subjects with BMI ≥ 19.0 ≤ 24.9 kg/m2, (n1=4); second group (G2) of overweight, pre-obese subjects with BMI ≥ 25.0 ≤ 29.9 kg/m2, (n2=4) and third group (G3) of obese subjects with BMI ≥ 30.0 ≤ 40.0 kg/m2, (n3=21). Semen samples were collected and assayed for Ins, T and standard semen analysis as well. Results: Obesity was associated with significantly increased serum insulin levels and IR, but with no significant difference in serum testosterone level. Significantly severe inverse correlations between serum levels of Ins and T, as well as between BMI and serum T were established. Positive correlation between serum and seminal concentration of Ins was found. A moderately strong negative correlation between concentrations of Ins and T in seminal plasma was confirmed. The significant differences in the average sperm concentration and teratozoospermal index were observed by comparison between obese and non -obese men. Conclusion: This pilot study showed that obesity and IR in general, adversely affects sperm parameters such as decreased sperm motility and increased teratozoospermal index. The pandemic spread of obesity necessitates further studies to clarify the additional links and mechanisms that are manifested at an early stage and are related to violations of reproductive function in obese men.
Authors and Affiliations
Todorova Katya, Rilcheva Violeta, Genova Mariana, Ilieva Victoria, Valova Teodora.
Keywords
Related Articles
- EP ID EP297979
- DOI 10.21474/IJAR01/7128
- Views 93
- Downloads 0
KHAT CHEWING PRACTICE ITS PERCEIVED HEALTH EFFECT AND ASSOCIATED PROBLEMS WITH KHAT CHEWING AMONG COMMUNITIES OF CHIRO TOWN.
Khat is found in the evergreen tree or large shrub consists of whole rash leaves and buds of a plant known as Catha edulis. It is an indigenous tree to Ethiopia, Kenya, and more than 20 different compounds are fund in kh...
EVALUATION DE LEFFET PROTECTEUR DU LAIT DE CHEVRE FERMENTE PAR LE KEFIR ET ENRICHI A LA CAROUBE CONTRE LULCERE GASTRIQUE INDUIT PAR LETHANOL CHEZ LE RAT.
La caroube ou fruit de caroubier est traditionnellement utilis?e contre les plaies et l?ulc?re gastro-duod?nal. Le k?fir du lait est consomm? pour ces actions b?n?fiques sur la flore intestinale et le transit gastro-inte...
EVOLUTION OF CONDUCTION MECHANISM IN THICK FILM RESISTORS.
When a printed and dried thick film resistor is subjected to firing, it undergoes many structural changes giving rise to various possibilities of electrical conduction. A study of these possibilities could be very intere...
BENEFITS OF DIGITAL GAME-BASED LEARNING (DGBL) FOR ENGLISH LEARNING.
The rapid development of English teaching method in recent years has brought out several new ideas to fruition, such as using entertainment media (such as movies or music) to support English learning. One of those entert...
EFFECT OF THE DIFFERENCE IN SOUND WAVE-BASED ATTRACTOR FREQUENCY ON THE CATCH OF HALFBEAK FISH (OXYPOHAMPHUS MICROPTERUS) USING TRAMMEL NET AT SURABAYA COAST.
The purpose of this study was to determine the effect of differences in frequency of sound wave-based attractors on the catch of halfbeak fish (oxyporhamphusmicropterus) on a three-layer trammel net on the Surabaya coast...