Abstract

INTRODUCTION: Pulmonary Function Tests (PFT) are important and frequently used for the preoperative evaluation of patients that will undergo cardiothoracic surgery and PFT are routinely required by anesthesiologists and surgical teams. Neutrophil Lymphocyte Ratio (NLR) is a biomarker recently reported by several studies to be associated with many diseases, and Platelet Lymphocyte Ratio and systemic immune inflammation index similarly. The aim of this study is to evaluate the presence of any correlation between PFT and theese ratios in patients without pulmonary disease or risk factors due to undergo CABG. METHODS: The retrospective study was conducted at our hospital and performed by reviewing data of patients undergoing CABG between January 2014 and August 2015. Demographical features, echocardiological results, complete blood count results, ratios of NLR, PLR, SII and PFT results were evaluated in patients undergoing CABG. RESULTS: Data of 61 patients were analyzed. A negative linear correlation was found between NLR and FEV1/FVC and NLR and MEF 75-25 % (p<0.01). ROC analysis was used to determine the cut off value for NLR when MMEF 75-25 < 80% and FEV1/FVC<80%. Cut off value of 2.105 was chosen for NLR with a sensitivity of 67.74% and specificity of 73.33% for FEV1/FVC <80% and sensitivity of 68.75% and specificity of 75.86% for MMEF75-25 <80%. DISCUSSION AND CONCLUSION: In patients without respiratory disease, due to undergo CABG, NLR shows an inverse correlation with PFT results. Our study is the first to put forth simple biomarkers calculated from CBC that can predict PFT.

Authors and Affiliations