Is There a Relationship Between Bupropion Plasma Levels and Blood Pressure Increase?
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 2
Abstract
Bupropion is largely used as an antidepressant and smoking cessation therapy. The aim of this work was to evaluate effects of increased bupropion plasma levels on blood pressure and heart rate in patients with depression. A total of sixty patients with a diagnosis of depression completed this naturalistic study. Bupropion was administered in 150 mg/day dose. Bupropion plasma levels were measured on the 7th and 14th day of treatment. Heart rate, systolic and diastolic blood pressure were measured for each patient on the 7th and 14th days of treatment. The results of this study did not show any statistically significant blood pressure or heart rate changes with elevating bupropion plasma levels. No significant difference in blood pressure or heart rate was observed by reaching the therapeutic plasma levels of bupropion. Although our results did not suggest any effect of bupropion plasma levels on heart rate and blood pressure, therapeutic benefit of bupropion to treat depression in hypertensive patients should be carefully weighed. Keywords: Blood pressure, Bupropion, Heart rate, Plasma level
Authors and Affiliations
Gül Eryılmaz ,, Gökben Hızlı Sayar, Barış Önen Ünsalver, Işıl Göğcegöz Gül, Nevzat Tarhan
Keywords
Related Articles
- EP ID EP377659
- DOI -
- Views 102
- Downloads 0
A Pharmacognostic and pharmacological overview on Bombax ceiba
Bombax ceiba is commonly known as silk cotton tree and semal which belongs to family Bombacaceae. Bombax ceiba is an important medicinal plant of tropical and subtropical India. Its medicinal usage has been reported in t...
Prevalance and Market Expension of Homeopathy in the Cancer Management
Abstract: Many cancer patients use homeopathic approaches to increase their bodys ability to fight cancer, improve their physical and emotional well-being, and alleviate their pain resulting from the disease or conventio...
Development and Validation of RP-HPLC Methods for the Estimation of API’s in Newanti Injection and Restozeal Tablets
Newanti injection comprises of 0.3 mg Biapenem in powder for injection, used as in vitro agent against anaerobes. Resveratrol is an antioxidant in Restozeal tablets. Since HPLC methods were more accurate, precise and sen...
Evaluation of Antibacterial Activity and Synergistic Effect of Different Conventional Antibiotics against Diarrheal Bacteria
Abstract: The present study has been carried out to evaluate the activity of antibiotics alone and antimicrobial potential of their combination against bacteria implicated in infectious diseases like diarrhoea in tropica...
Pattern of Utilization of Anticancer Medications at a Tertiary Care Hospital in South-South Nigeria
Globally, cancer constitutes a major cause of morbidity and mortality with increasing incidence and prevalence. Drug utilization studies promote rational use of drugs. This retrospective, observational and descriptive st...