Is There a Relationship Between MMP-9 and Oxidised LDL in a Normal Population?
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 8
Abstract
Abstract: Oxidised LDL, a marker of systemic oxidative stress, and MMP-9, a collagenase found in vulnerable atherosclerotic plaques have been implicated in the initiation and/or progression of atherosclerosis. Infiltrating inflammatory cells interact with the extracellular matrix and oLDLs, contributing to and increased production of MMP-9 by macrophages. The MMPs contribute to the development of de novo atherosclerotic plaques as well as to the rupture of these plaques by degrading the associated extracellular matrix.A study was carried out to determine whether there was an association between these two markers of inflammation in samples from a normal population to see if they could be used as predictors of early coronary heart disease. The results showed that overall, in a normal population there was no association between the plasma levels of oLDL and MMP-9 except when other intrinsic factors were included such as fibrinogen or insulin, then there was a correlation. Keywords:Atherosclerosis, oxidised low density proteins (oLDL), matrix metallo-proteinase 9 (MMP-9), fibrinogen, insulin.
Authors and Affiliations
Stephen Mortlock
Keywords
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