Block characteristics of different doses of intrathecal dexmedetomidine when combined with low dose heavy bupivacaine for gynecological surgeries: a double blind, randomised comparative study
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 6
Abstract
Abstract: Intrathecal dexmedetomidine is being explored as a new adjunct to bupivacaine for neuraxial anesthesia. Objective is to study variability in various parameters of sensory and motor blockade using different doses of dexmedetomidine intrathecally while reducing the dose of heavy bupivacaine in gynecological surgeries. A unicenter, parallel, double blind randomized prospective controlled trial. 75 females undergoing gynecological procedures, fulfilling the inclusion/exclusion criteria received a total volume of 2.5 ml drug intrathecally, accordingly: D1 (n=25) - hyperbaric bupivacaine 7.5 mg (1.5ml) with 5 μg (1ml) dexmedetomidine. D2 (n=25) - hyperbaric bupivacaine 7.5 mg (1.5ml) with 7.5 μg (1ml)dexmedetomidine. D3 (n=25) - hyperbaric bupivacaine 7.5 mg (1.5ml) with 10 μg (1ml) dexmedetomidine. The outcomes of the study were planned before data collection began. Statistically (p=0.005), onset of T10 level sensory block was dose dependant, fastest in D3 (2.36±0.81 min) and slowest in D1 (3.12±0.83 min) and so was the onset of motor block (p<0.001), time in D3 (2.32±0.63 min) and in D1 (3.56±0.96 min). In peak level, two segment regression time and total time of sensory block, there was no intergroup difference. Dexmedetomidine did effect the total time of motor block, but not in dose dependent pattern (p=0.037). With neurexial dexmedetomidine , onset of sensory and motor block is faster with increasing the dose. Total volume of bupivacaine can be reduced to significant levels to achieve a higher peak level, prolonged two segment regression time and total time of sensory and motor block. Keywords:Neuraxial, bupivacaine, dexmedetomidine, alpha 2 agonist, adjuncts.
Authors and Affiliations
Ekta Sharma, Bharti Gupta, R. K. Verma, Vishal Devra
Keywords
Related Articles
- EP ID EP373124
- DOI -
- Views 59
- Downloads 0
Sex assignment and Re-assignment: A pediatric endocrinologist perspective; more than three decades of experience
The birth of a child with disorder in sex development (DSD) poses a major psychological impact on the family and involves a specialized and experienced multi-disciplinary team to work with the family. There has been pro...
Dual Targets in PCR and its Usage for the Molecular Characterization of Mycobacterium Tuberculosis
Tuberculosis (TB) is an infectious bacterial disease caused by Mycobacterium tuberculosis. Diagnostics methods includes Serological, Radiological and Microbiological investigations. The current study was done on the dual...
The Effect of Chandra Bhedi Pranayama (Left Nostril Breathing) on Cardiorespiratory and Autonomic Parameters
The effect of Chandra Bhedi Pranayama (Left nostril breathing) on autonomic functions were investigated in healthy male volunteers, The Left nostril breathing (LNB) Comprised 30 Males in age groups of 18-25-years. Initia...
Plasma Protein Patterns in Sudanese Patients with Schistosoma Mansoni Using Protein Electrophoresis
Abstract: Schistosomiasis is the third most devastating tropical disease in the world (200,000 deaths annually). A protective granulomatous response is initiated by the arrival of eggs in the liver. The response results...
An interesting case report- Xanthogranulomatous Pyelonephritis masquerading as a tumour
Xanthogranulomatous pyelonephritis is a rare chronic inflammatory disorder of kidney accounting for 1% of cases of pyelonephritis. We report a case in a 67 year old male patient who was diagnosed as emphysematous pyelone...