Plasma Protein Patterns in Sudanese Patients with Schistosoma Mansoni Using Protein Electrophoresis
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 4
Abstract
Abstract: Schistosomiasis is the third most devastating tropical disease in the world (200,000 deaths annually). A protective granulomatous response is initiated by the arrival of eggs in the liver. The response results in chronic liver fibrosis as the infection progresses. This complication has an impact on the liver function. The aim of the study was to evaluate the effect of Schistosoma Mansoni on the plasma protein patterns. The study was conducted on 32 adult’s patients with Schistosoma Mansoni and 41 adults’ healthy individuals at New Half a (Sudan) during the period from 2008 to 2010. Serum protein was analysed by electrophoresis and photometric method. The mean values in g/dL± SD of the different protein patterns in the patients group are as follows: Total proteins: (7.19 g/dL ± 0.80 ), albumin: (3.29 g/dl ± 0.61 ), α-1: (0.43 g/dl ± 0.22 ), α-2: (1.37 g/dl ± 0.43 ), β-1: (1.12 g/dl ± 0.68), β-2: (0.58 g/dl ± 0.21 ), and γ: (0.87 g/dl ± 0.50). The mean values in g/dL± SD of the different patterns in the control group are as follows; Total proteins: (7.29 g/dl ± 0.61), albumin: (4.01 g/dl ± 0.54). α-1: (0.27 g/dl ± 0.12), α-2: (1.26 g/dl ± 0.46), β-1: (0.94 g/dl ± 1.02), β-2: (0.57 g/dl ± 0.18), and γ- globulins: (0.84 g/dl ± 0.18). The results showed that there was a significant decrease in albumin and an increase in α-1 globulins in patients group when compared to the control group. There were no differences in the remaining patterens. The study concluded that schistosoma mansoni infection may be one of the causes of low plasma albumin and increased alpha-1 globulin in Sudan. The Hypoalbuminemia may be attributed to decreased synthesis due to less albumin mRNA in hepatocytes or attributed to malabsorption due to damaged intestinal mucosa resulting from the extrusion of large numbers of eggs. Keywords: electrophoresis, schistosoma mansoni, New Halfa
Authors and Affiliations
Omer Balla Ibrahim, Ahmed Mohammedani, Elamin Mohamed, Amira Abd Alla, Asmaa Omer Balla, Ali Sied Ahmed
Keywords
Related Articles
- EP ID EP371188
- DOI -
- Views 93
- Downloads 0
A Study on Blood Biochemical Markers in Carcinoma Breast
Abstract: Carcinoma breast is the most common malignancy and the most common cause of cancer deaths in Indian women. Tumor markers are biochemical indicators of the presence of tumor. Various tumor markers have been stud...
Oculi auricular features of incomplete Goldenhar syndrome
Goldenhar syndrome is a rare congenital abnormality including a triad of ocular dermoid cyst, preauricular skin tags and vertebral dysplasia. The current case is an incomplete syndrome for the vertebral features were lac...
Recent Advances in Structure-Based Protein Engineering
The last decade has seen an exponential increase of protein structures solved by X-ray crystallography, NMR and cryo-electron microscopy. The existing information on the protein crystal structure and various computationa...
Gross Morphological Changes in Placenta of Hypertensive Pregnancy
Abstract: The study was conducted at the Department of ANATOMY in collaboration with the Department of Obstetrics and Gynaecology in Gauhati medical collge and hospital, Guwahati from june 2009 to may 2012. Placentae exp...
Effects of Ethanolic Extract of Bauhinia Variegata Leaves Alone and In Combination with Metoclopramide on Induced Model of Acute Colitis in Rabbits
Abstract: The exact reasons of UC are still unidentified; however, numerous factors have been implicated in the pathophysiology of the disease. Inflammatory mediators such as cytokines, reactive oxygen species, also 5-HT...