Is there a relationship between polycystic ovary syndrome and the FABP1 gene rs2197076 single nucleotide polymorphism?
Journal Title: Experimental Biomedical Research - Year 2019, Vol 2, Issue 1
Abstract
Aim: Polycystic ovary syndrome (PCOS) is a multifactorial, endocrine, and metabolic disorder seen in 10%-20% of women of reproductive age. Due to the close relationship observed between the increased risk of type 2 diabetes and insulin resistance and the polymorphism of the fatty acid binding protein 1 (FABP1) gene rs2197076 single nucleotide polymorphism (SNP), we investigated the frequency of the FABP1 gene rs2197076 SNP in patients with PCOS. Methods: This is a prospective case-control study. The study included 151 women—75 patients with PCOS and 76 healthy women. A real-time polymerase chain reaction was performed for the FABP1 rs2197076 polymorphism. Additionally, biochemical and hormonal levels of the patients were studied. Results: Menstrual irregularities, the body mass index (BMI), hirsutism scores, the luteinizing hormone / follicular stimulating hormone ratio, dehydroepiandrosterone sulfate and testosterone levels were significantly higher in the PCOS group than in the control. There was no significant difference between the PCOS and control groups in terms of FABP1 rs2197076 genotype distribution and FABP1 rs2197076 allele frequency distribution. Conclusion: There was no increase in the genotype distribution and allelic frequency of the FABP1 gene rs2197076 SNP in PCOS patients. Further studies are needed on this subject.
Authors and Affiliations
Arzu Guler Karakuz, Mustafa Ayhan Ekici, Mehmet Ata Topcuoglu, Selma Duzenli, Cansu Kara Oztabag
Keywords
Related Articles
- EP ID EP50821
- DOI https://doi.org/10.30714/j-ebr.2019147581
- Views 251
- Downloads 0
Serum Uric acid is correlated with HbA1c levels in type 2 diabetes mellitus
Aims: Uric acid is the product of purine metabolism and elevated serum uric acid levels are associated with many metabolic conditions. In present retrospective analysis, we aimed to compare serum uric acid levels of well...
Can gestational exercise have a positive effect on cognitive functions resulting from brain injury? A rat study
Aim: The effects of gestational exercise on potential pathological conditions is not known yet. Therefore, in the present study, it was aimed to evaluate the effects of forced running exercise on LPS-induced brain damag...
Comparison of platelet volume indices in acute coronary syndrome
Aim: To compare the parameters showing the platelet volume index in unstable angina pectoris (USAP), non-ST elevation myocardial infarction (non-STEMI) and ST elevation myocardial infarction (STEMI). Methods: The plat...
Roles of the systemic inflammatory response biomarkers in the diagnosis of cancer patients with solid tumors
Aim: Cancer is still considered as one of the leading causes of mortality worldwide. Various tumor factors have been used for the diagnosis and follow-up of solid tumors; however, their clinical features remains controve...
Effects of gestational exercise on hyperoxia-induced brain damage in the newborn
Aim: Preterm infants encounter hyperoxia relatively early on as they leave the intrauterine environment earlier than expected, while also being exposed to a higher level of hyperoxic stress due to insufficiencies in thei...