IS6110 gene in Mycobacterium tuberculosis complex in Tuberculosis meningitis-Clinical Applications for Disease Monitoring
Journal Title: Scholars Academic Journal of Biosciences - Year 2017, Vol 5, Issue 1
Abstract
Tuberculosis meningitis (TBM) is the most common form of chronic infection of central nervous system. Regardless of the extent of the problem, the general diagnostic outlook is discouraging specifically; there is no generally accepted early confirmative diagnostic protocol available for TBM. In the current work, 16 Cerebrospinal Fluid (CSF) cases were considered for the molecular characterization.02 CSF came positive for the Nested PCR targeting IS6110 gene, considered to be positive for the presence of mycobacterium tuberculosis DNA. It was also seen that the positive cases were with increased ADA titer. The clinical manifestations of the positive cases were matching with those for the tuberculosis meningitis.
Authors and Affiliations
Bhavana Singh, Vishal Khandelwal, Urvashi Agarwal, Sandhya Mangla, Uma Shankar, Anjana Goel, Aditya Saxena, A. K. Bhatia, Meenakshi Bahuguna, Narotam Sharma
Keywords
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