Isolated multidrug-resistant ESBL enterobacteriaceae strains in wounds are susceptible to amikacin
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2015, Vol 3, Issue 2
Abstract
Enterobacteriaceae is a family of facultative aerobic bacteria thriving well in wounds that are prone to hospital borne infections infections, in specific post-operative wounds. Recent observations reflect the increased incidence and prevalence of ESBL (Amber’s class A Penicillinases) that are resistant to 3rd generation cephalosporins (extended spectrum cephalosporins) and aztreonam. The major ESBL producing microbes isolated in these wound infections Escherichia coli and Klebsiella pneumoniae. As random use of antimicrobials effective against these strains pose a threat to increase in virulence and resistance in these strains, a systematic survey was done to identify the rate of incidence ESBLs in diverse infection types and trending susceptibility pattern to antibiotics is a routine need. From the profiled microorganisms in the 289 patients sampled in the hospital using routine microbiological techniques, Enterobacteriaceae isolates were screened for ESBL production and antibiotic susceptibility using disk diffusion tests. Results indicated that ESBL producers are more prevalent in burns, surgical site infections and abscess, but not in traumatic wounds; Klebsiella pneumoniae (42.5 %) were more prevalent than Escherichia coli (40%) and were more sensitive to amikacin. This kind of study ensures judicious usage of antibiotics to prevent development of new resistance mechanisms by the ESBL producers.
Authors and Affiliations
Ravichandran B
Keywords
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