Isolated thrombocytopenia in acute malaria: association with vitamin B12 and folic acid levels
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 1
Abstract
Background: The objective of the present study was to evaluate the associationof thrombocytopenia with vitamin B12 and folic acid levels in cases of acute malaria and also to see if any difference exists between cases of falciparum and vivax malaria. Materials and Methods: It was a hospital based observational study including 50 patients of diagnosed malaria with thrombocytopenia presenting to the medical OPD/ IPD. The thick and thin slides were prepared according to the WHO guidelines. The platelet counts were visually confirmed by a clinical hematologist after the counts were done by an auto analyzer machine. Laboratory tests done on these patients consisted of full blood counts, liver enzymes, renal function, vitamin B12 levels, folic acid levels anderythrocyte sedimentation rate. Data was analyzed using SPSS software ver. 21. Results: Prevalence of low folate/ Vitamin B12 levels was 56% (Table 1). About one fourth (26%) cases had grade I thrombocytopenia while 18% and 56% had grade II and III thrombocytopenia respectively. A significant association was observed between low folate/ Vitamin B12 levels and severity of thrombocytopenia while no difference was observed between low folate/ Vitamin B12 levels and type of malaria. Conclusion: Vitamin B12 and folic acid deficiency is positively associated with isolated thrombocytopenia in cases of acute malaria. Thus early Vitamin B12 and folic acid supplementation might help in obliviating the severity of malaria and should be given in all cases of acute malaria.
Authors and Affiliations
Piyush Jain, Manish Pendse, Gayatri Pendse, Madhu Hingorani
Keywords
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