ISOLATION AND CHARACTERIZATION OF WITHAFERIN-A FROM THE WITHANIA SOMNIFERA (ASHWAGANDHA)
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 1
Abstract
The research work is related to an improved process of isolation & characterization of Withaferin-A from withania somnifera (Sanskrit: Ashawagandha, English: Winter cherry). Withania somnifera, commonly known as Ashwagandha, is a valued herb in Ayurvedic medicine. Roots, leaves and preparations of the plant are traditionally used as tonic, hypnotic, sedative and diuretic. W. somnifera mainly contains withanolides including withaferin-A which are specific to the Solanaceae family. Withanolides are biologically active secondary metabolites present in roots and leaves of W.somnifera. In the present study, we have standardized the protocol for the isolation of Withaferin-A from the Ashwagandha punchang. Withaferin A possess anti-inflammatory and anti-stress properties. This study contains newer and conventional method of isolation of Withaferin-A from Withania somnifera as well Quantitative and qualitative techniques involved in the purification of the compound was followed throughout this research work. In this study, we have taken different trials based on hydro-alcoholic solvent composition. Based on different solvent extraction process pure 98% Withaferin-A was successfully isolated.
Authors and Affiliations
Bali Reddy Keesara
Keywords
Related Articles
- EP ID EP294649
- DOI 10.22270/jddt.v7i1.1375
- Views 93
- Downloads 0
PHYTOCHEMISTRY AND MEDICINAL USES OF MORINGA OLEIFERA: AN OVERVIEW
This paper review the retrospective studies on the Moringa oleifera at molecular level. There are about thirteen species of Moringa trees in the family Moringaceae. Moringa oleifera Lam. (synonym: Moringa pterygosperma G...
LIQUISOLID COMPACTS: A PROMISING APPROACH FOR SOLUBILITY ENHANCEMENT
At present 40% of the drugs within the development pipelines, and approximately 60 % of the drugs coming directly from synthesis area unit poorly soluble. Solubility is one of the important parameter to obtain desired c...
MULTI-COMPONENT DRUG DELIVERY OF PACLITAXEL
Co-delivery systems have been proved to be of much benefit to the anti-cancer drug field. In order to make these drugs successful, nano-particles usage has been promoted. The mini-review has brought forward some of the m...
PHARMACEUTICAL STANDARDIZATION OF APAMARGA KSHARA YOGA
Objective: Apamarga Kshara Yoga (APK), a classical Ayurvedic formulation containing Apamarga Kshara (alkaline substance of Achyranthes aspera Linn.), Manahshila (Arsenic Disulphide) and Gomutra (cow’s urine) is effecti...
BILOSOME: A BILE SALT BASED NOVEL CARRIER SYSTEM GAINING INTEREST IN PHARMACEUTICAL RESEARCH
The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants with peculiar structure and self-assembled t...