ISOLATION AND STRUCTURAL ELUCIDATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITIES COMPOUNDS FROM CANTHIAM COROMENDELICUM
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract The present study deals with the identifying a Squalene from medicinal plants for pharmaceutical application. Squalene was isolated from Canthiam coromendelicum using soxhlet apparatus. Methanol is a good solvent for extraction of the Squalene. The crude extractions of C. coromendelicum shows many Secondary metabolites present in the extracts such as Squalene, phytol, n-Butyl are major compounds to find out from the plant profile using GC-MS, UV-Vis, FT-IR, HPTLC, NMR and Mass. Then it was used for further pharmaceutical applications such as antioxidant, antibacterial and cytotoxicity assay. The Squalene possess enhanced characteristic of antioxidant activity against for their free radicals (DPPH, NO, SO, H2O2), antibacterial activity against Salmonella typi, E. Coli, Pseudomonas putida, Staphylococcus aureus. It shows good cytotoxicity activity against Hep-2 cells. The characterization analysis proved that the isolated Squalene would be a good and potential drug for cancer. In future it will be useful in many biomedical applications.
Authors and Affiliations
Arulprakash. P, Sasidharan. P, Jayachitra. A
Keywords
Related Articles
- EP ID EP330677
- DOI -
- Views 82
- Downloads 0
LIQUID CHROMATOGRAPHY MASS SPECTROMETRIC METHOD FOR QUANTIFICATION OF POTENTIAL GENOTOXIC IMPURITY 2, 6-DIAMINOPYRIDINE IN MINODRONIC ACID
Abstract A new, simple, accurate and sensitive method was developed for the quantification of potential genotoxic impurity 2, 6-Diaminopyridine in Minodronic acid using Liquid Chromatographic Mass Spectrometry (LCMS). Th...
ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT BIOACTIVE FACTORS DERIVED FROM MARINE FUNGAL ENDOPHYTES; A REVIEW
Abstract The marine-derived fungi has proven to be a very rich source of extremely potent compounds that have demonstrated a number of biologically active compounds with varying degrees of action such as anticancer, anti...
DESIGN AND IN VITRO CHARACTERIZATION OF KETOPROFEN CORE IN CUP PULSATILE TABLETS FOR CHRONOMODULATED DRUG THERAPY.
Abstract The aim of the present investigation is to intend, develop and evaluate a pulsatile drug delivery containing a core-in-cup based system of dry coated tablet of ketoprofen based on chronomodulated approach for ma...
ETHOSOMAL DRUG DELIVERY SYSTEM: A REVIEW
The vesicles have been well known for their important in cellular communication and particle transportation for many years. Researchers have understood the properties of vesicle structures for use in better drug delivery...
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-UPLC METHOD FOR THE SIMULTANEOUS QUANTIFICATION OF SOFOSBUVIR AND VELPATASVIR IN FINISHED DOSAGE FORM
A simple, rapid, accurate, precise and economical reverse phase Ultra performance liquid chromatographic method was developed for simultaneous quantification of two anti-viral drugs, viz., Sofosbuvir and Velpatasvir. The...