Isolation, Characterization and Pharmacological Studies of A Flavonol Glucoside From Trichilia connaroides (W.&A.) Bentilizen
Journal Title: International Journal of Research in Pharmacy and Science - Year 2011, Vol 1, Issue 2
Abstract
A flavonol glucoside, namely populnin (Kaempferol-7-O-glucoside ) was isolated from the leaves of Trichilia connaroides (W.&A.) Bentilizen. Investigation of the methanolic leaf extract of Trichilia connaroides for analgesic activity led to the isolation of populnin. Structural elucidation of the isolated compound was achieved by IR, 1H-NMR and LC-MS. The methanolic extract and the isolated compound were tested for analgesic activity using the Eddy’s hot plate method and the Acetic acid induced writhing test. In both tests populnin showed significant analgesic activity (P<0.001) at a dose of 50 mg/Kg b.w. The methanolic extract and populnin did not show any acute toxicity. Isolation of the flavonol glucoside and the activity observed in this study may explain in part the use of the tree in traditional medicine as a crude analgesic drug.
Authors and Affiliations
Meharoon Dudekula, Vanita Somasekhar, Ashok Purnima,
Keywords
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