Isolation of α-Glucosidase Inhibitors From Soil Borne Aspergillus terreus and Cladosporium herbarum
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Microorganisms and plants produce different novel compounds such as antibiotic, antitumor, cytotoxic, anti-inflammatory, etc. Many primary metabolites, such as amino acids, vitamins and nucleotides, which are capable of making secondary metabolites of microbes that, constitute half of the agriculture, industry and pharmaceuticals compounds with many essential products in the market today. -glucosidase inhibitors from the fungal origin would show potential inhibition to -glucosidase enzymes. These enzymes are involved in the breakdown of starch and other molecules containing polysaccharide components, such as the glycolipids and glycoproteins in biological membranes. This study was carried out with an aim to isolate -glucosidase inhibitors from fungi of different places of Nepal. The terrestrial soil samples were collected in sterile plastic bags from different places of Kathmandu, Pokhara and Nawalparasi during the month of May 2013 by random sampling method. In this study, twenty four fungi have been tested for production and primary screening of glucosidase inhibitor. Among twenty four identified fungi, two fungi, Aspergillus terreus and Cladosporium herbarum produced more than 60% inhibition to -glucosidase enzyme. These organisms were found potential fungi to produce -glucosidase inhibitors in significant percentage and can be used for the further study.
Authors and Affiliations
Subedi M,, Rajbhandari GS. 2
Keywords
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- DOI 10.9790/3008-1105020107
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