Formulation and Evaluation of Etoricoxib Oro Dispersable Tablets by Direct Compression Method
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Oral disintegrating tablet (ODT) is defined as “A solid dosage form containing medical substances or active ingredient which disintegrates rapidly usually within a matter of seconds when placed upon the tongue”. The main aim of the present study is to formulate Etoricoxib oral disintegrating tablets. Etoricoxib is a selective COX-II inhibitor which acts by inhibiting the COX–2 enzyme and decreases the incidences of side effects associated with these agents. Conventional tablets of Etoricoxib are not capable of rapid action, which is required for faster drug effect onset and immediate relief from pain. Etoricoxib ODT’s are prepared by direct compression method using Cross povidone, Cross carmellose sodium, Sodium starch glycolate and Calcium silicate as the super disintegrants. The prepared tablets were characterized for their hardness, weight variation, disintegration time, wetting time, tablet thickness, friability, and in vitro dissolution studies.DSC Studies were also performed. The ability of the tablet to release the drug faster depends on the concentration and type of super disintegrant. In this study the oral disintegrating tablets containing Cross carmellose sodium as the super disintegrant in the concentration of 10% shows better release of drug. About 98.6% of the drug was released in 10 mins from the tablets. Therefore, based on the physico chemical properties, in vitro drug release profile and mouth feel formulation F 10 containing 10% of Cross carmellose sodium is optimised as the best formulation. DSC study shows no drug excipient interaction.
Authors and Affiliations
Lakshmi Usha Ayalasomayajula, Radha Rani Earle, Prasanthi T,, V. Harika,, N. RamyaSree
Keywords
Related Articles
- EP ID EP383985
- DOI 10.9790/3008-1102036470
- Views 108
- Downloads 0
Mosquito Species Diversity And Distribution in Three Riverine Communities in Taraba State, North-Eastern Nigeria
Mostmosquitoes are nuisance and public health problem because the females consume blood and transmit diseases. Studies were carried out between September, 2015 and August 2016 to determine the composition and abundance o...
Physico-Chemical Analyses and Status of Arbuscular Mycorrhizal Fungi from Rhizosphere Soils of Solanaceous Vegetables
Soil characters were studied for the ability of the soil to support Arbuscular Mycorrhizal Fungal (AMF) colonization and spore density. Results of three rhizosphere soil samples of Tomato, Chilli and Brinjal from six dif...
Antimicrobial Effect of Chromolaena Odorata (L.) and Vernonia Amygdalina Del Leaf Extract on Clinical Isolates from Infected Wound
Herbal medicines has been widely used and forms an integral parts of primary health care in most developing countries today due to its effectiveness, availability and low cost. In the present study, the antimicrobial eff...
In-Vitro Antibacterial Effect of Crude Extract of Chromolaena Odorata Leaves on Wound Isolates
Medicinal plants have played an important role in prevention and control of diseases. The abundance of plants on the earth’s surfaces has led to an increasing interest in the investigation of different extracts obtained...
Circulating Resistin Concentrations, Inflammatory Biomarkers and Insulin Resistance in Iraqi Patients with Chronic Kidney Failure
Background: Resistin in humans is mainly produced by blood-derived leukocytes and mononuclear cells. Resistin antagonizes the effects of insulin on glucose metabolism in liver and skeletal muscle, interacts with and rein...