Circulating Resistin Concentrations, Inflammatory Biomarkers and Insulin Resistance in Iraqi Patients with Chronic Kidney Failure
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 6
Abstract
Background: Resistin in humans is mainly produced by blood-derived leukocytes and mononuclear cells. Resistin antagonizes the effects of insulin on glucose metabolism in liver and skeletal muscle, interacts with and reinforces inflammatory pathways. Objective: Evaluation of the resistin level as inflammatory factor in patients with chronic renal failure. Patients and Methods: Study was conducted at the department of Biochemistry, College of Medicine / University of Baghdad and AL-Karama Hospital during the period from March 2016 to March 2017. This cross-sectional study was composed of 50 consecutive patients with CRF according to the National Kidney Foundation practice guidelines and 30 apparently healthy control subjects was matched. Measurements of fasting plasma glucose and serum levels of triglyceride, total cholesterol, creatinine were done by colorimetric method, followed by calculation of estimated glomerular filtration rate (eGFR). Insulin resistance was estimated using the homeostasis model assessment for insulin resistance (HOMA-IR) index. Serum levels of resistin, high sensitivity CRP were estimated by ELISA technique. Excluding criteria include diabetic obese subjects. Results: The levels of resistin, insulin , CRP and HOMA were significantly higher in patients with CKD than in the control subjects (p≤0.05). Patients with elevated CRP (>6 mg/L) had significantly higher resistin levels than those with lowered CRP (≤6 mg/L). A Significant positive correlation was demonstrated between serum levels of resistin and serum levels of insulin, HOMA and creatinine (r=0.54,r=0.77, r=0.302, respectively, p≤0.05) and a significant negative correlation was found between serum resistin and eGFR (r=-0.2, p≤0.05). Conclusion: The result of this study revealed that high level of resistin in patients with high sensetive C – reactive protein may suggested that resistin elevation related to inflammation associated with chronic renal failure.
Authors and Affiliations
Ass. Prof Dr. Manal kamal Rasheed, Ass. Prof, Dr. Maysaa Jalal Majeed, Lecturer Dr. Wafa Mansor Merza, Dr. Mohammed kamal Rasheed, Prof Dr. Halla Ghazi Mahmoud
Keywords
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- EP ID EP392395
- DOI 10.9790/3008-1206020510.
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