Isolation of dermatophytes associated with patients of tinea corporis not responding to standard terbinafine treatment protocol
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2017, Vol 22, Issue 2
Abstract
Background: Dermatophytoses is a superficial fungal infection of keratinized tissue. Oral terbinafine is effective in the treatment of superficial dermatophyte infections, generally achieving cure in > 80% of patients.The occurrence of terbinafine resistant clinical isolates is rare one case has been documented and with abnormally low susceptibility to terbinafine do exist. Hence, this study was undertaken to isolate dermatophytes associated with patients of tinea corporis not responding to standard terbinafine treatment protocol. Material and Methods: A total of the 187 cases were clinically diagnosed as tinea corporis.The skin scrapings were collected two times from each patient, before instituting treatment and one week after completion of terbinafine treatment in clinically resistant cases. Results: In 64 (34.2%) patients with T. rubrum and T. mentagrophytes infections were resistant to treatment with terbinafine. Patients had persistent lesions and all these were positive by direct microscopy or culture or both in their post treatment clinical specimens. Discussion: Treatment of cutaneous dermatophytosis has increasingly become difficult. Among various options, topical terbinafine for 4 weeks appears to be the treatment of choice. However, an appropriate dose and duration of administration which can produce mycologic cure and prevent recurrence remains elusive.
Authors and Affiliations
Neha Sharma, Uma Tendolkar
Keywords
Related Articles
- EP ID EP494925
- DOI -
- Views 77
- Downloads 0
Morbidity pattern among elderly population at tertiary care hospital: A retrospective study
In general, “elderly” age group is defined as persons aged 65 years and above. The two extremes of life child and elderly need special care. Elderly life is full of problems – physical, social and economic. While ageing...
[i][/i]Preliminary physiological and cytological screening of callus of Vigna catjang Walp (in Vitro)
The present paper aim is to preliminary physiological and cytological study of callus, which is obtained from Vigna catjang walp.Growth of callus is determined by fresh weight and dry weight of callus, mitotic index and...
Awareness of Eye Donation in an Urban Population in Aurangabad, Maharashtra
Purpose: To assess the awareness of eye donation and willingness to pledge the eyes for donation in urban population in Aurangabad district, Maharashtra. Methods: Study was carried out from January 2013 to July 2013. To...
Association between Periodontitis and Cardiovascular Diseases: A Clinicobiochemical Study
Introduction: The periodontal tissues mount an immune inflammatory response to bacteria and their products and the systemic challenge with these agents also induce a major vascular response. Oral infection models ha...
A Perception of Maternal Mortality among Women in an Urban Slum Area of South India
Introduction: Every pregnant woman hopes pregnancy to be a smooth process and expect to give birth safely as pregnancy and child birth is considered a normal physiological process. But, this is not happening at least in...