Isolation of dermatophytes associated with patients of tinea corporis not responding to standard terbinafine treatment protocol
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2017, Vol 22, Issue 2
Abstract
Background: Dermatophytoses is a superficial fungal infection of keratinized tissue. Oral terbinafine is effective in the treatment of superficial dermatophyte infections, generally achieving cure in > 80% of patients.The occurrence of terbinafine resistant clinical isolates is rare one case has been documented and with abnormally low susceptibility to terbinafine do exist. Hence, this study was undertaken to isolate dermatophytes associated with patients of tinea corporis not responding to standard terbinafine treatment protocol. Material and Methods: A total of the 187 cases were clinically diagnosed as tinea corporis.The skin scrapings were collected two times from each patient, before instituting treatment and one week after completion of terbinafine treatment in clinically resistant cases. Results: In 64 (34.2%) patients with T. rubrum and T. mentagrophytes infections were resistant to treatment with terbinafine. Patients had persistent lesions and all these were positive by direct microscopy or culture or both in their post treatment clinical specimens. Discussion: Treatment of cutaneous dermatophytosis has increasingly become difficult. Among various options, topical terbinafine for 4 weeks appears to be the treatment of choice. However, an appropriate dose and duration of administration which can produce mycologic cure and prevent recurrence remains elusive.
Authors and Affiliations
Neha Sharma, Uma Tendolkar
Keywords
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