The effect of levothyroxine substitution on lipid profile parameters in patients of subclinical hypothyroidism in tertiary care centre of kumaon region
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 3
Abstract
Introduction- Subclinical hypothyroidism (SCH) also called as mild thyroid failure is defined as the presence of serum thyroid stimulating hormone (TSH) above the statistically defined upper limit of the reference range, with a serum free thyroxine (T4) and tri-iodothyronine (T3) within the reference range. Various studies of serum lipid profile parameters in SCH showed inconsistent results. Further studies done to quantify the effect of levothyroxine substitution had also shown conflicting results. This study was therefore planned to study the effects of SCH on lipid profile parameters and to evaluate the effect of thyroxine replacement therapy on thyroid and lipid profile in area around Kumaon region. Materials and Methods- out of total 175 subjects, 75 euthyroids were taken as control and 100 newly diagnosed SCH patients as cases. Estimation of thyroid function tests (TSH, T3, T4) and lipid profile parameters [Total cholesterol (TC), Low Density Lipoprotein cholesterol (LDLc), Triglycerides (TG), High Density Lipoprotein cholesterol(HDLc)] were estimated in all subjects after an overnight fast. Out of 100 SCH patients 58 selected patients were given thyroxine replacement therapy and were followed up after 3 months with repeat thyroid and lipid profile. Results- In the present study the mean levels of TC, LDLc, TG were significantly high in comparison to euthyroid controls. HDLc levels were raised in SCH patients but insignificant statistically. There was a significant decrease in TC and LDLc levels in SCH patients after 3 months of thyroxine replacement therapy. The mean levels of TG and HDLc were also reduced after treatment but were insignificant. Conclusion – This study conclude that dyslipidemias are present in SCH cases as compared to euthyroid controls. The thyroxine replacement therapy in selected patients demonstrated the favorable effects on TC, LDLc and in the ratios of TC/HDLc and LDLc/HDLc.
Authors and Affiliations
Sangeeta Singh, Seema Gupta, Paramjeet Singh, Basant Joshi
Keywords
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