Issues of therapy for biliary pathology in children: the choice of the optimal solution
Journal Title: Здоров`я дитини - Year 2018, Vol 13, Issue 0
Abstract
Background. Diseases of the hepatobiliary system are one of the most important problems of pediatric gastroenterology. Lesions of the biliary tract are associated with persistent changes in lipid metabolism that contributes to the prolonged cholestasis and to the progression of the biliary pathology. The purpose of this study was to evaluate the efficacy and safety of Ursofalk® in the comprehensive therapy of biliary tract diseases and comorbid pathology in children. Materials and methods. The results of examination and integrated treatment of 55 children aged 5 to 18 years (31 girls and 24 boys) with diseases of the biliary tract and comorbid pathology were analyzed. The criteria for inclusion of patients in the study were: the presence of diseases of the biliary tract accompanied by biliary sludge and blood lipid disorders. Diagnostic complex included: analysis of clinical data, ultrasound examination of abdominal organs, biochemical blood analysis (liver tests, lipid disorders). Depending on the comorbid pathology, all children received comprehensive treatment within a month. Patients were divided into two groups depending on choleretic therapy: group 1 (main) received conventional cholagogues, group 2 (comparison) — Ursofalk®. Licensed software products (Statistica, Excel) were used for statistical processing of the obtained data. Results. By the end of the treatment with Ursofalk® we observed positive dynamics in patients’ condition and laboratory indicators. In patients who received Ursofalk®, the manifestations of pain syndrome and dyspepsia completely disappeared. Children from the comparison group still had pain syndrome, a feeling of heaviness in the right upper quadrant and dyspepsia. The use of Ursofalk® normalized the parameters of the bile structure and the biochemical parameters of lipid metabolism. We registered a significant (p < 0.05) decrease in the incidence of impaired bile homogeneity — by 65.5 % in children from the main group. In children of the comparison group, it decreased only by 27.3 %. Positive dynamics of biochemical parameters was observed in both groups of patients, but with significant changes (p < 0.05) in the group of children taking Ursofalk®. Conclusions. Ursodeoxycholic acid (UDCA) use is pathogenetic justified for the correction of functional and metabolic disorders in biliary and comorbid pathologies in children. Ursofalk® administration in the comprehensive therapy of the diseases of the biliary system in children led to the rapid regression and relief of clinical symptoms and the improvement of laboratory-instrumental indicators. Ursofalk® is a reference product of UDCA. Availability of the officinal form of Ursofalk® in a special form for children (suspension) allows UDCA to be used in childhood, starting from the first days of life.
Authors and Affiliations
O. V. Shutova, N. V. Pavlenko, O. N. Babadganyan, I. G. Solodovnichenko
Keywords
Related Articles
- EP ID EP292277
- DOI 10.22141/2224-0551.13.0.2018.131174
- Views 90
- Downloads 0
Antibiotic therapy of community-acquired pneumonia in children: comparison of international guidelines and current practice in Ukraine
Background. Respiratory diseases are a serious medical and social problem in pediatrics. The aim of the study was to research the current scientific sources for the treatment of community-acquired pneumonia in children,...
Nutritional and pharmacological correction of calcium and vitamin D deficiency in children
Maintaining the optimal level of calcium in the body of children, especially infants, is an essential condition that is necessary to ensure the state of health. However, the use of natural vitamin D-containing foods does...
Quorum sensing inhibitors of bacteria Streptococcus pneumoniae
The scientific review systematizes information on LuxS/AI-2 and ComABCDE quorum sensing systems of bacteria Streptococcus pneumoniae. It is emphasized that biofilms of bacteria Streptococcus pneumoniae are one of the mec...
Pathogenetic Significance of Antimicrobial Peptides in the Implementation of Antibacterial Protection in Children with Cystic Fibrosis
Objective: to investigate the factors increasing the colonization of respiratory system with Ps.аeruginosa in children with cystic fibrosis. Materials and methods. The study involved 37 children with cystic fibrosis at...
Nasopharyngeal Carriage of Streptococcus Pneumoniae in Inmates of Children’s Homes: Serotype Repertoire and Susceptibility to Antimicrobial Agents
The article presents the results of the first in Ukraine investigation on the prevalence of nasopharyngeal pneumococcus carriage in healthy children up to 5 years, living in children’s homes. It is shown that the childre...