It’s all in your genes! - Prospects of Gene Therapy in Dentistry.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Abstract: The main objective of medical and dental sciences is to understand the physiological processes occurring in humans and alleviate pain and suffering from the world. Diseases which have a multifactorial etiology are often a challenge for the clinician to treat and conventional treatment modalities do not always give satisfactory results. The missing link in these conditions is genetics, i.e. there are several disorders which are caused by alteration of genes coding for specific proteins. Gene therapy is a method by which the defective gene is repaired or replaced by a therapeutic gene with the help of suitable vectors. It has a wide array of applications from the treatment of single gene to multi-gene disorders. Salivary glands and keratinocytes are excellent target sites for gene therapy and are often used for treating systemic conditions. Its dental applications range from treatment of pain, salivary gland disorders, oral cancer, bone repair, orthodontic tooth movement, tooth regeneration and DNA vaccination for dental caries and periodontal disease. The aim of this article is to discuss the principles of gene therapy, its future prospects in the field of dentistry and the role of a dentist as a ‘Gene therapist'.
Authors and Affiliations
Dr. Esha Mukherjee, Aumiyo Das
Keywords
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