JAK-2V617F Mutation in Acute Leukemia (South Egypt Experience)
Journal Title: International Blood Research & Reviews - Year 2014, Vol 2, Issue 1
Abstract
Aim: To search for JAK2V617F mutation in patients with acute myeloid and acute lymphoblastic leukemia in south Egypt. Study Design: JAK2V617F mutation detected by amplification refractory mutation system (ARMS) -PCR. Place and Duration of Study: Department of clinical pathology and department of medical oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt, between December 2010 and December 2012. Method: We included 90 patients (58 men and 32 women; age range 2-67 years) with denovo acute leukemia (30 acute myeloid leukemia and 60 acute lymphoblastic leukemia), JAK-2 V617F mutation using ARMS-PCR was done for all the patients. Results: JAK-2 V617F mutation was absent in all of the studied patients. Conclusion: Our results confirm the finding published previously which reported that JAK2 V617F mutation is very rare or absent in acute leukemia.
Authors and Affiliations
Hosny Badrawy, Abeer Ibrahim
Keywords
Related Articles
- EP ID EP242414
- DOI 10.9734/IBRR/2014/5340
- Views 155
- Downloads 0
Assessment of Thrombolytic Activity of Five Bangladeshi Medicinal Plants: Potential Source for Thrombolytic Compounds
Aim: The aim of our project work was to assess the thrombolytic activity of five common Bangladeshi plant extract in different solvent. Five plants are Geodorum densiflorum (Shankhamul), Pistia stratiotes (Topa Pana), Sm...
Primary Testicular Lymphoma: A Study of 11 Cases
Primary testicular lymphoma (PTL) is an uncommon extranodal presentation constituting 1% of all NHL and 5% of all testicular neoplasm. The objective of our study was to identify the presenting signs and symptoms, treatme...
The Cell Based Model of in-vivo Coagulation: A Work in Progress
The goal of this article is to review the evolution of theories of coagulation and their proposed models to serve as a tool. When reviewing the research and practice literature that was published in the context of these...
Incidence of Rh Antigens, Phenotype & Probable Genotype in the Population of Gwalior and Chambal Region, Central India
Introduction: Rhesus (Rh) antigen was discovered in 1940 by Karl Landsteiner and Wiener. In later years, because of its immunogenecity along with ABO grouping, RhD antigen testing was made mandatory before issuing a comp...
A Preliminary Study of the Effect of Alchornea laxiflora on Haematological Parameters and Organ Weight in Albino Rats
Aim: The aim of this study is to investigate the effects of ethanol extract of Alchornea laxiflora on internal organs as well as haematological indices of rats. Methodology: The plant materials were air dried and grinded...