JAK-2V617F Mutation in Acute Leukemia (South Egypt Experience)
Journal Title: International Blood Research & Reviews - Year 2014, Vol 2, Issue 1
Abstract
Aim: To search for JAK2V617F mutation in patients with acute myeloid and acute lymphoblastic leukemia in south Egypt. Study Design: JAK2V617F mutation detected by amplification refractory mutation system (ARMS) -PCR. Place and Duration of Study: Department of clinical pathology and department of medical oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt, between December 2010 and December 2012. Method: We included 90 patients (58 men and 32 women; age range 2-67 years) with denovo acute leukemia (30 acute myeloid leukemia and 60 acute lymphoblastic leukemia), JAK-2 V617F mutation using ARMS-PCR was done for all the patients. Results: JAK-2 V617F mutation was absent in all of the studied patients. Conclusion: Our results confirm the finding published previously which reported that JAK2 V617F mutation is very rare or absent in acute leukemia.
Authors and Affiliations
Hosny Badrawy, Abeer Ibrahim
Keywords
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- EP ID EP242414
- DOI 10.9734/IBRR/2014/5340
- Views 154
- Downloads 0
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