Kalanchoe pinnata aqueous extract safety and potential cardioprotective effects in isoprenaline treated rats
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 5
Abstract
Introduction: Kalanchoe pinnata (Crassulaceae) aqueous extract antihypertensive property has been proven. This study aimed to evaluate the safety and potential cardioprotective effects of the extract in isoproterenol treated rat. Methods: A total of 35 adult wistar rats were randomly and evenly distributed into groups 1-7 then treated for 28days. Control groups 1-3 received 10mL/kg water (per os, neutral), 150mg/kg isoproterenol (ISO, sc, 48 and 24hours prior to sacrifice, negative) and ISO plus 10mg/kg propranolol (per os, ten days prior to sacrifice, positive). Safety test groups (4-6) received K. pinnata extract (50, 100 and 200mg/kg per os). Cardioprotective test group 7 received K. pinnata (100mg/kg per os) and ISO. The sacrifice of rats was carried out on day 29 and blood collected for haematological and biochemical analyses. Liver, kidney and heart were collected weighed and preserved for histopathological analysis. Results: There was no observable sign of toxicity. No significant difference was observed between the relative weight of the heart from groups 1-7. The platelet value dropped from 794.7x10 /L (group 2) to 284x10 /L (group 7, p<0.05). An elevated value of creatine Kinase-MB (20.64U/L) was obtained in group 2, which decreased in other groups (P<0.05). In group 7, however, the extract (100mg/kg/day) reduced (P>0.05) the level of CK-MB compared to group 2. The level of triglycerides was elevated in group 2, 4 and 6 compared to group 1. Histopathological analysis of the heart showed the safety of the extract. Conclusion: We demonstrated that K. pinnata extract (100-200mg/kg/day, per os) might be cardioprotective.
Authors and Affiliations
Orelien Sylvain Mtopi Bopda, Nathalie Nadège Chendjou Koumtouzi, Danielle Bilanda, Désiré Paul Djomeni Dzeufiet, Christian Tiambo Keambou, Théophile Dimo
Keywords
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