Antihyperglycemic activity of Zanthoxylum chalybeum stem bark extract in diabetic rats
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 3
Abstract
Zanthoxylum chalybeum Engl. (Rutaceae) stem bark is used by communities in Africa and Asia to manage diabetes mellitus. This study determined the anti-hyperglycemic effect of Z. chalybeum aqueous stem bark extract in streptozotocin-induced diabetic rat. The plant was obtained from Machakos County, Kenya and a stem bark extract prepared. Rats were divided into experimental (n=5), negative control (n=5) and positive control groups (n=5). Diabetes was induced in each rat in experimental groups by a single dose intraperitoneal injection of Streptozotocin at 45mg/kg body weight. The plant extract was administered orally to the experimental rats at dosages of 10, 100 and 1000mg/kg body weight for 14 days. The negative control group was left untreated while the positive control group was treated orally with glibenclamide (10mg/kg body weight). The effect of the extract on blood glucose, body weight, food and water intake and oral glucose tolerance were determined in all rats in the experimental and control groups. The aqueous stem bark extract exhibited significant antidiabetic activity compared to the untreated diabetic controls (P<0.05). Additionally, there was no significant difference between the extract fed diabetic rats and the normal controls. Furthermore, extract treated diabetic animals recorded a comparatively decreased weight loss which was dose dependent. These results suggest that the aqueous stem bark extract of Z. chalybeum possesses significant antihyperglycemic activity. This study thus corroborates the traditional use of the plant for the management of diabetes. However, further studies are required to identify the active ingredient(s) and determine the mode of action.
Authors and Affiliations
Kimani C. N, Mbaria J. M, Suleiman M, Gakuya D, Kiama S. G
Keywords
Related Articles
- EP ID EP49629
- DOI -
- Views 217
- Downloads 0
Investigation of anti-arthritic activity (in-vitro models) of Hibiscus hispidissimus Griffith
Aim of the experiment: The present study was designed to investigate the anti-arthritic potential of the plant Hibiscus hispidissimus. Materials and Methods: The aerial parts of the plant was collected, dried and extra...
Butanol soluble fractions of Cissus cornifolia methanolic leaf extract and behavioural effects in mice
Cissus cornifolia Baker - Planch (Family: Vitaceae) is used for various central nervous system disorders. The present study reported the sedative and central nervous depressant effects of fractions (butanol soluble port...
Evaluation of some plant extracts for nemato-toxic potential against juveniles of Meloidogyne incognita in vitro
Aqueous leaf extracts were utilized to assess the nematicidal or nematostatic property on second stage juvenile of Meloidogyne incognita. The juvenile were incubate at various concentration of leaf extract viz., 250, 50...
Pharmacognostical and Phytochemical Evaluation of Arka Taila gel- External dermal application
Arka Taila is an important Ayurvedic formulation containing Arka (Calotropis procera (Ait)R. Br), Haridra (Curcuma longa Linn.), Sarsapa (Brassica nigra). 15% aerosol was added in Arka Taila for obtaining Arka Taila ge...
Antioxidant activity, total phenolic and total flavonoid contents of stem back and root methanolic extracts of Calotropis procera
Calotropis procera it is known for traditional Kenyan medicinal system and it is used for it has previously been employed for treatment various diseases. This study aimed at examining methanolic extract of C. procera t...