Ketamine: from narcotic analgesics to antidepressants
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 8
Abstract
Ketamine compound was firstly synthesized for more than 60 years. It is widely used in clinical anesthesia due to its potent analgesic effect and lower deleterious impacts on circulatory and respiratory functions. Very recently, its rapid and long-lasting antidepressant effect attracted increasing attentions in the topic field. We therefore reviewed the pharmacological properties of ketamine, its clinical application as a narcotic analgesic, and antidepressant effect of its metabolites.
Authors and Affiliations
JIANG Chenqi*, XU Xiangqing, XIE Li, LIU Cunming, YANG Chun(*Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China)
Analysis of influencing factors of osteoporosis in postmenopausal patients with type 2 diabetes mellitus and construction of nomogram model
"<b>Objective</b> To explore the influencing factors of osteoporosis (OP) in postmenopausal patients with type 2 diabetes mellitus (T2DM), and try to establish a predictive model of nomogram in developing OP in postmenop...
Relationship of cerebrospinal fluid choline acetyltransferase and cholinesterase with 〖JP〗postoperative delirium in elderly patients
"<b>Objective</b> To detect the concentrations of choline acetyltransferase (ChAT) and cholinesterase (ChE) in cerebrospinal fluid of elderly patients and explore their relationship with postoperative delirium (POD)....
Artificial intelligence advancements in breast cancer ultrasound screening
Ultrasound is the first-line screening method for breast cancer. The application of BI-RADS makes the ultrasound diagnosis of breast diseases relatively consistent, but it is still affected by subjective factors of opera...
Clinical significance of circulating tumor cell detection in elderly patients with esophagogastric gastric junction adenocarcinoma
Objective To investigate the relationship between circulating tumor cells (CTCs) and clinical characteristics and prognosis of elderly patients with esophagogastric junction adenocarcinoma (AEG) by detecting CTCs in thei...
Preoperative controlling nutritional status on the prognosis of postoperative gastric cancer patients: a Meta-analysis
<b>Objective</b> To evaluate the prognostic value of controlling nutritional status score (CONUT) in patients undergoing gastrectomy for gastric cancer. <b>Methods</b> CNKI, Wanfang, China Biomedical Literature Library,...