KIKUCHI-FUJIMOTO DISEASE- CLINICOPATHOLOGICAL ANALYSIS OF 35 CASES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 42
Abstract
BACKGROUND Kikuchi-Fujimoto disease has become a common cause of lymphadenopathy in many parts of the world. The cause and pathogenesis still remains a mystery. Systemic morphological studies of the disease are few from India. Aims of this study were- 1. To delineate the clinical and lab features as well as lymph node morphology of Kikuchi-Fujimoto disease and to compare the above features with previous studies. 2. To compare the proliferative subtype of the disease with high-grade lymphoma and devise a scoring system that aids in differential diagnosis. MATERIALS AND METHODS 35 consecutive patients diagnosed to have Kikuchi-Fujimoto Disease on lymph node biopsy in Calicut Medical College during the period January 2006 to December 2007 were evaluated for their clinical details. Their lymph node biopsies were reassessed; 15 lymph node biopsies reported as high-grade non-Hodgkin lymphoma were compared with proliferative subtype of Kikuchi Fujimoto Disease. RESULTS The mean age in the study was 25.4 years with female: male ratio of 2.5. Cervical nodes were involved in almost all the cases. Significant number of cases were associated with leukopaenia. Of the 35 cases 17 were proliferative type (48.6%), 16 were necrotising type (45.7%) and 2 were xanthomatous type (5.7%). A scoring system was devised for discriminating between KFD and high-grade lymphoma noting certain microscopic features. CONCLUSION Kikuchi-Fujimoto disease is a benign self-limiting condition, which commonly affects cervical lymph nodes of young women. Histologically, the node can be subtyped into 3 categories. A scoring system devised can be used to discriminate between proliferative subtype of Kikuchi-Fujimoto disease and high-grade lymphoma.
Authors and Affiliations
Freena Rose, Rajan Gopalan Nair
Keywords
Related Articles
- EP ID EP219914
- DOI 10.18410/jebmh/2017/510
- Views 102
- Downloads 0
ATYPICAL KAWASAKI DISEASE- DILATATION OF ASCENDING AORTA AND PERIPHERAL GANGRENE
BACKGROUND The aetiology of Kawasaki disease is still unknown and no single pathognomonic clinical or laboratory finding for the diagnosis has been identified. However, paediatricians sometimes encounter febrile children...
AN OBSERVATIONAL PROSPECTIVE STUDY OF ADVERSE DRUG REACTIONS IN NEW SMEAR POSITIVE PATIENTS OF PULMONARY TUBERCULOSIS TREATED UNDER DIRECTLY OBSERVED TREATMENT IN CONTINUATION PHASE IN GENERAL MEDICINE OPD AT GULBARGA INSTITUTE OF MEDICAL SCIENCES, KALABURAGI
BACKGROUND The objective of this study was to study the adverse drug reaction profile of New Sputum-Smear Positive (NSP) patients of pulmonary tuberculosis (PTB) treated under DOTS in category-I, in continuation phase. A...
HOMONYMOUS HEMIANOPIA: RECOVERY OF VISUALFIELDS IN ACUTE STROKE
Homonymous hemianopia the most common cause is stroke. The field defect of vascular origin the prognosis for spontaneous recovery is poor. The objective of this case was to describe the characteristics of spontaneous rec...
CERVICAL CANCER SCREENING: KNOWLEDGE, ATTITUDE AND PRACTICES IN A PRIMARY HEALTH CENTRES IN RURAL INDIA
Cervical cancer is the most common preventable cancer noted in Indian women, having a major impact on their lives. Approximately, 70% of people reside in villages in India. Hence, the objectives of this study were to fin...
A RARE CASE REPORT OF EMPHYSEMATOUS CYSTITIS IN A DIABETIC PATIENT
: Emphysematous cystitis is a rare disease caused by gas fermenting bacterial and fungal pathogens. Clinical symptoms are non-specific and diagnostic clues often arise from the unanticipated imaging findings. The clinica...