KIKUCHI-FUJIMOTO DISEASE- CLINICOPATHOLOGICAL ANALYSIS OF 35 CASES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 42
Abstract
BACKGROUND Kikuchi-Fujimoto disease has become a common cause of lymphadenopathy in many parts of the world. The cause and pathogenesis still remains a mystery. Systemic morphological studies of the disease are few from India. Aims of this study were- 1. To delineate the clinical and lab features as well as lymph node morphology of Kikuchi-Fujimoto disease and to compare the above features with previous studies. 2. To compare the proliferative subtype of the disease with high-grade lymphoma and devise a scoring system that aids in differential diagnosis. MATERIALS AND METHODS 35 consecutive patients diagnosed to have Kikuchi-Fujimoto Disease on lymph node biopsy in Calicut Medical College during the period January 2006 to December 2007 were evaluated for their clinical details. Their lymph node biopsies were reassessed; 15 lymph node biopsies reported as high-grade non-Hodgkin lymphoma were compared with proliferative subtype of Kikuchi Fujimoto Disease. RESULTS The mean age in the study was 25.4 years with female: male ratio of 2.5. Cervical nodes were involved in almost all the cases. Significant number of cases were associated with leukopaenia. Of the 35 cases 17 were proliferative type (48.6%), 16 were necrotising type (45.7%) and 2 were xanthomatous type (5.7%). A scoring system was devised for discriminating between KFD and high-grade lymphoma noting certain microscopic features. CONCLUSION Kikuchi-Fujimoto disease is a benign self-limiting condition, which commonly affects cervical lymph nodes of young women. Histologically, the node can be subtyped into 3 categories. A scoring system devised can be used to discriminate between proliferative subtype of Kikuchi-Fujimoto disease and high-grade lymphoma.
Authors and Affiliations
Freena Rose, Rajan Gopalan Nair
Keywords
Related Articles
- EP ID EP219914
- DOI 10.18410/jebmh/2017/510
- Views 110
- Downloads 0
FRACTURE SHAFT HUMERUS: INTERLOCKING
The incidence of humeral fracture has significantly increased during the present years due to the population growth and road traffic, domestic, industrial, automobile accidents & disasters like tsunami, earthquakes, head...
A STUDY OF PREVALENCE OF HYPOTHYROIDISM IN CHOLELITHIASIS
BACKGROUND For decades, there has been discussion whether thyroid disorders could cause gallstone disease. Gallstone formation is a complex process involving various mechanisms affecting the flow of bile and bile content...
WHY BECOME A DOCTOR? EVALUATION OF MOTIVATIONAL FACTORS FOR SELECTING MEDICAL PROFESSION AS CAREER
After pre-university course, students have to take an important decision regarding their career depending on their interest, family aspirations, past experiences and their limited knowledge of various careers. The object...
THE STUDY ON STROKE IN HIV PATIENTS
BACKGROUND Stroke and HIV infection are both common medical problems in day-to-day clinical practice. According to the few studies done1 in India, the prevalence of stroke in general population in India is 205 cases/1 la...
ATRIAL MYXOMA AS A CAUSE OF STROKE IN THE YOUNG
Cardiac Myxoma is a source of emboli to the CNS and elsewhere in the vascular tree. However non-specific systemic symptoms and minor embolic phenomenon may be overlooked in the absence of any history of cardiac symptoms....