Kinetics of the decomposition and the estimation of the stability of 10% aqueous and non-aqueous hydrogen peroxide solutions
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2014, Vol 27, Issue 4
Abstract
In this study, the stability of 10% hydrogen peroxide aqueous and non-aqueous solutions with the addition of 6% (w/w) of urea was evaluated. The solutions were stored at 20°C, 30°C and 40°C, and the decomposition of hydrogen peroxide proceeded according to first-order kinetics. With the addition of the urea in the solutions, the decomposition rate constant increased and the activation energy decreased. The temperature of storage also affected the decomposition of substance, however, 10% hydrogen peroxide solutions prepared in PEG-300, and stabilized with the addition of 6% (w/w) of urea had the best constancy.
Authors and Affiliations
Maria Zuń, Dorota Dwornicka, Katarzyna Wojciechowska, Regina Kasperek, Marzena Rządkowska, Ewa Poleszak
Prevalence of viruses HBV, HCV and HIV in blood donors at the Regional Centre of Blood Donation and Blood Treatment in Poznan in the years 2008-2010
Currently we may observe increasing demand for blood and its components as well as blood derivatives. Technological progress in viral diagnostics and the use of Good Manufacturing Practice (GMP) rendered the blood safety...
The influence of the viscosity of the ointment vehicles magisterial topical preparations, on the speed transfer of biologically active substances
The aim of this study was to analyze the morphological parameters (viscosity, viscous elasticity and the rate of volatile component loss) of salicylic and boric acid-containing magisterial formulae (ointments). Moreover,...
Impact of the grasping test on women’s cardiovascular systems, and the possibility of replacing the orthostatic tolerance test with it
The aim of this study was to test the impact of the Grasping Test (GT) on the female cardiovascular system and to ascertain the possibility of using this to replace the Orthostatic Tolerance Test (OT). In this study, 15...
Doxorubicin induces delayed heart and liver mitochondrial depolarisation
The effect of repeated administration of doxorubicin (DOX) on heart and liver morphology, mitochondrial function and redox equilibrium was investigated in rats, contributing in explanation of delayed cardiomyopathy. Male...
The influence of excipients on dissolution of caffeine from granules
Four formulas of granules with caffeine were chosen to examine the influence of excipients on dissolution profiles of active substance from this drug form. The formula I: caffeine 1.0 parts, potato starch 69,3 parts, lac...