Knowledge of the Molecular Signaling Pathways Improves the Chances of Treatment of Gastrointestinal Stromal Tumors
Journal Title: Cancer Studies & Molecular Medicine – Open Journal - Year 2015, Vol 2, Issue 1
Abstract
Gastrointestinal Stromal Tumors (GISTs) are the most common mesenchymal (nonepithelial) tumors of the gastrointestinal tract. A better molecular understanding of this entity, as Christopher L. Cordless in Modern Pathology in 20141 demonstrated, GISTs mainly a result from two-level changes in two Oncogenes: KIT oncogene (75%) and PDGFRA oncogene (α receptor platelet-derived growth factor) which occurs in about 10% of cases; the remaining 15% are designated wild type tumors.
Authors and Affiliations
Joana Espiga de Macedo
Keywords
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- EP ID EP552145
- DOI 10.17140/CSMMOJ-2-109
- Views 107
- Downloads 0
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