L-Ergothioneine Supplement Protect Testicular Functions In Cisplatin-Treated Wistar Rats.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
The present study was designed to investigate the role of L-ergothioneine supplement against cisplatin-induced reproductive toxicity in male wistar rats, regarding the antioxidant and cytoprotectant property of this supplement, and redox indices generated by cisplatin administration during administration.Twenty adult male wistar rats randomly divided into four groups (n=5) were used in this study and subjected to treatment as follows; Group I (control) received 10mL/kg distilled water for 14days; Group II (Cis alone) received a single dose of 7 mg/kg IP of cisplatin on the 10th day. Group III (Erg alone) received 10mg/kg Erg orally for 14days and group IV (Cis+erg) received both Erg and Cis. Body and reproductive organ weight, Sperm analysis, serum level of reproductive hormones (Testosterone, FSH and LH), biochemical (CAT, MDA, SOD, GPx) and histological (H&E dye) evaluations of testis were performed. Treatment with Cisplatin shows a decrease in sperm count, serum testosterone concentration, SOD, GPx, CAT and increased abnormal sperm morphology, percentage dead sperm cells, MDA level and causes histopathological damage. However, L-ergothioneine supplement significantly prevent these deleterious effect of Cis. The result from this study shows that L-erg supplement has protective effects on Cisplatin-induced testicular dysfunction via its antioxidant and cyto-protectant activities. Thus, it has the potential for use as therapeutic adjuvants against reproductive toxicity in patients undergoing Cisplatin therapy.
Authors and Affiliations
Ayobami DARE, Olugbemi Tope OLANIYAN, Maimuna Abdu SALIHU, Kehinde Linus ILLESANMI
Keywords
Related Articles
- EP ID EP431612
- DOI 10.9790/3008-1401010613.
- Views 50
- Downloads 0
Enhancement of Dissolution Rate of Ramipril Tablets by Solid Dispersion Technique
Ramipril is an ACE inhibitor mainly used for management of mild to severe hypertension and myocardial infarction. The poor solubility and wettability of Ramipril leads to poor dissolution and hence showing variations in...
Less Known Preventive Herbal Drugs Used Against Piles By Tribals and Rural Communities of Rayalaseema Region, Andhra Pradesh
The objective of the present study is to collect firsthand information from local/herbal healers and rural people of Rayalaseema region, Andhra Pradesh used for piles. Ethno botanical interviews were conducted in the dif...
Analgesic and Anti-Inflammatory Studies on The Roots Argemone Mexicana Linn(FAMILY: PAPAVERACEAE)
Analgesic and anti inflammatory studies of the ethanol extract of the roots of A. mexicana were studied in mice and rats respectively. Acetic acid-induced writhing in mice and hind paw oedema in rats were determined. The...
Case Study On Ekakushtha ( Psoriasis ) With Ayurvedic Management.
Psoriasis is non infectious chronic inflammatory disease of skin characterized by well defined erythmatous plaques with silvery scale which have a predilection for extensor surface and scalp and by chronic fluctuating co...
Prevalence of vitamin D deficiency in adults in the coastal regions of Odisha, India
Background and objectives: Vitamin D is a fat-soluble vitamin belonging to secosteriods. It is responsible for intestinal absorption and bioavailibity of calcium and phosphorus.Synthesisof vitamin D in response to ultrav...