Labour Epidural Analgesia: A Randomised Double Blind Comparative Study of 0.1% Levobupivacaine with Fentanyl vs. 0.1% Ropivacaine with Fentanyl
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 7
Abstract
Introduction: Levobupivacaine and ropivacaine are suitable alternatives to bupivacaine for labour analgesia as they produce less motor blockade, decreased incidence of instrumental deliveries and less toxicity. Aim: To study the efficacy of epidural levobupivacaine and ropivacaine in intermittent doses for labour analgesia. Materials and Methods: In the present prospective, randomised, double blind study, 60 parturients consenting for labour epidural analgesia using intermittent top-up technique were randomly allocated to receive either levobupivacaine 0.1% with Fentanyl 2 mcg/mL (LF) or ropivacaine 0.1% with Fentanyl 2 mcg/mL (RF). Haemodynamic parameters, sedation score, onset and quality of analgesia, sensory and motor blockade, local anaesthetic requirement, side effects, duration of labour, mode of delivery, neonatal outcome and maternal satisfaction were compared between groups. Statistical analysis included students unpaired t-test, chi-square test, Fischer’s-exact test, Mann-Whitney U-test as appropriate with p<0.05 was considered statistically significant. Results: Demographic and obstetric parameters were comparable in two groups. Both drugs were comparable with respect to haemodynamics, sedation score, onset and quality of analgesia, sensory and motor blockade, local anaesthetic requirement, duration of labour, mode of delivery, neonatal outcome, maternal satisfaction and side effects. One parturient (3.33%) in RF group developed motor block of Bromage grade 1 as compared to none in LF group without any statistical significance. No parturient required Rescue analgesia. Conclusion: The combinations of low concentration (0.1%) of epidural levobupivacaine and ropivacaine with fentanyl provide equivalent labour analgesia, without significant maternal or fetal side effects.
Authors and Affiliations
Debasmita Das, Deepali Pankaj Thakur, Bharati Anil Tendolkar
Keywords
Related Articles
- EP ID EP525925
- DOI 10.7860/JCDR/2018/31764.11769
- Views 70
- Downloads 0
Effect of Technique of Disinfection by Ultrasonic Nebulization on Accuracy of Vinyl Polysiloxane Impressions
ABSTRACT Introduction: To prevent cross-contamination, impressions should be properly disinfected after removing from the mouth. To be efficacious, a successful disinfection must maintain the physico-chemical properties...
Patent Vitellointestinal Duct with Patent Urachus Presenting as Umbilical Discharge
Patent urachus with patent vitellointestinal duct is a rare combination to present in the same patient. We present a rare case of one year old male child with such a condition presenting with complaint of discharge from...
CDX-2 Protein Expression in Premalignant and Malignant Lesions of Gallbladder
ABSTRACT Introduction: CDX2 is a caudal type homeobox gene encoding a transcription factor that play important role in regulating proliferation and differentiation of the intestinal epithelium. Recent studies demonstrat...
Pregnancy Outcome of Abnormal Nuchal Translucency: A Systematic Review
Introduction: Nuchal Translucency (NT) is the sonographic form of subcutaneous gathering of liquid behind the foetal neck in the first trimester of pregnancy. There is association of increased NT with chromosomal and non...
Fairness of Health Financing before and after Introduction of Iranian Health Sector Evolution Plan: A Case Study
ABSTRACT Introduction: Since out-of-pocket payments of household are a serious obstacle to the equitable utilization of health services, paying attention to the direct payment of households and, consequently, incidence o...