Langerhans Cell Sarcoma of Thyroid: A Rare Differential for a Thyroid Swelling
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 11
Abstract
Langerhans Cell Sarcoma (LCS) is a rare disease arising from antigen-presenting cells. The literature on LCS is largely limited to case series and only 67 such cases have been reported till date. We report a case of 27-year-old female presenting as a thyroid swelling. Computerized tomography (CT) scan showed diffuse enlargement of thyroid and patient underwent total thyroidectomy. Final diagnosis on histopathology and Immunohistochemistry (IHC) was langerhans cell sarcoma of the thyroid. Patient was advised adjuvant chemotherapy, however she defaulted and later presented to us with a disseminated disease. This is the 18th case of head and neck LCS to be reported and the first case of primary thyroid origin in the world literature. The diagnosis of LCS is by combination of histopathology and IHC and multi- modality treatment offers the best chance of cure.
Authors and Affiliations
Suhas K Rajappa, Dharma Ram, Makhan L Lohiya, Sunil Pasricha, Ajay K Dewan
Keywords
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- EP ID EP367015
- DOI 10.7860/JCDR/2017/31842.10808
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