Latanoprost Timolol Regime Vs Brimonidine Timolol Regime in Primary Open Angle Glaucoma Uncontrolled with Timolol Alone
Journal Title: People's Journal of Scientific Research. - Year 2016, Vol 9, Issue 1
Abstract
A randomized, prospective, interventional comparative study was conducted in 50 patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT) for 13 months. The eyes were categorized as Group A consisting 48 eyes and group B consisting 48 eyes. The purpose of the study was to compare the efficacy and safety of treatment regimens with a combination of 'Latanoprost with Timolol' and 'Brimonidine with Timolol' in patients of primary open angle glaucoma uncontrolled with timolol alone. Patients of group A were given a combination of Latanoprost 0.005% with timolol 0.5% once daily and group B were given a combination of Brimonidine 0.2% with timolol 0.5% twice daily. The outcomes were difference from baseline to month 6 in mean IOP reduction, mean best corrected visual acquity (BCVA), mean vertical cup:disc ratio (CDR), mean average retinal nerve fibre layer (RNFL) thickness, mean average rim area, mean deviation (MD) and pattern standard deviation (PSD). Mean baseline IOP levels in mmHg were 27.58(SD 3.28) in group A and 28.08(SD 3.11) in group B. At month 6, levels were 15.64(SD 1.42) in group A and 17.27(SD 2.35) in group B. Outcome at 6 month in BCVA, CDR, average RNFL and average rim area also showed significant difference between the groups. The adverse events occurred equally, 42 in group A and 44 in group B. The combination of Latanoprost/Timolol given once daily has more efficacy, equal safety and tolerability as compared to the combination of Brimonidine/Timolol given twice daily.
Authors and Affiliations
Jitendra Kumar, , Naveen Sirohi, , Shruti Vaish
Keywords
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