Left ventricular Diastolic dysfunction in Female Rheumatoid Arthritis Patients: Association to Insulin Resistance and Metabolic Syndrome
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 10
Abstract
Background: Inflammation characteristic of active RA, likely plays a major role in cardiovascular disease Cardiac involvement (pericardial, myocardial and endocardial) is known in patients of Rheumatoid arthritis. Aim of this work: is to investigate left ventricular diastolic dysfunction (DD) in mildly active or remittent rheumatoid arthritis female patients and its association to insulin resistance and metabolic syndrome. Patients and Methods: A total of forty eight middle aged female patients with rheumatoid arthritis compared to thirty age and sex matched apparently healthy participants as a control group were included. According to echocardiographic findings patients were classified into two subgroups: patients without diastolic dysfunction (without DD) and patients with diastolic dysfunction (DD). Results: We found left diastolic dysfunction was less frequent in RA patients who are controlled or nearby (DAS28 score ≤ 3.5) than reported by other previous studies 7/48 (14.6%). Patients with diastolic dysfunction had statistically significant higher serum insulin level, fasting blood sugar, TNFα, insulin resistance and metabolic syndrome than RA patient without diastolic dysfunction. Conclusion: We found left diastolic dysfunction was less frequent in patients how are controlled or nearby (DAS28 score ≤ 3.5), with a significant association between diastolic dysfunction and presence of insulin resistance with metabolic syndrome.
Authors and Affiliations
Eglal M Kenawy
Keywords
Related Articles
- EP ID EP214572
- DOI -
- Views 52
- Downloads 0
Carotid Intima Media Thickness Measurements in Nigerian Pre-dialysis CKD Patients
Background: Cardiovascular disease complications are the commonest causes of mortality in patients with Chronic Kidney Disease (CKD). Carotid intima-media thickness (CIMT) measurements provide information on arterial wal...
A Study of HIV in Elderly Patients with Special Reference to SocioDemographic Profile and Response to Anti Retroviral therapy
Background: While HIV infection is commonly thought to affect younger adults, there are an increasing number of patients over 50 years of age living with the condition. With the introduction of highly active antiretrovir...
Impact of ‘‘Advance Patients Care Plan’’ in Cardiovascular Disorders
Background and Objective: Cardiovascular deaths and disorders have increased at a fast rate in low and middle-income countries. In India most of population pays their healthcare bills out of their own pocket, so there is...
Atypical Atrial Flutter in a Patient with Ischemic Stroke – A Rare ECG Finding
Electrocardiogram (ECG) changes are observed in patients with acute stroke and may create confusion with ECG changes found in cardiac disorders. Various ECG changes are observed in patients with acute stroke including rh...
Prevalence of osteoarthritis according to modified ACR and EULAR-2009 among patients attending orthopaedics department in a tertiary care hospital, Puducherry
Osteoarthritis is one of the most common rheumatic diseases and is the leading cause of pain and disability in most countries worldwide. The present study aimed to measure the proportion of knee osteoarthritis and its ri...