Less is More: Benefit of Achieving Very Low Low-Density Lipoprotein-Cholesterol Levels on Cardiovascular Events
Journal Title: Heart Research – Open Journal - Year 2017, Vol 4, Issue 1
Abstract
Low-density lipoprotein-cholesterol (LDL-C) reduction with statin therapy is one of the most pivotal interventions for atherosclerotic cardiovascular disease (ASCVD) prevention and treatment. The risk of coronary artery disease (CAD) decreases with reduction in LDL-C but there is no established level at which the risk becomes insignificant. The current practice guidelines for the primary prevention of CAD recommends calculation of ASCVD risk instead of targeting a particular cholesterol level for initiating statin therapy.1,2 It is recommended that patients with known CAD or those presenting with acute coronary syndromes (ACS) receive high intensity statin independent of baseline LDL-C levels. However, the target LDL-C goal for secondary prevention of CAD remains unclear. Besides reducing LDL-C, statins also have pleiotropic effects, such as lowering inflammation and stabilizing atherosclerotic plaques.
Authors and Affiliations
Amber Fatima
Keywords
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- EP ID EP558250
- DOI 10.17140/HROJ-4-134
- Views 159
- Downloads 0
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