Less is More: Benefit of Achieving Very Low Low-Density Lipoprotein-Cholesterol Levels on Cardiovascular Events
Journal Title: Heart Research – Open Journal - Year 2017, Vol 4, Issue 1
Abstract
Low-density lipoprotein-cholesterol (LDL-C) reduction with statin therapy is one of the most pivotal interventions for atherosclerotic cardiovascular disease (ASCVD) prevention and treatment. The risk of coronary artery disease (CAD) decreases with reduction in LDL-C but there is no established level at which the risk becomes insignificant. The current practice guidelines for the primary prevention of CAD recommends calculation of ASCVD risk instead of targeting a particular cholesterol level for initiating statin therapy.1,2 It is recommended that patients with known CAD or those presenting with acute coronary syndromes (ACS) receive high intensity statin independent of baseline LDL-C levels. However, the target LDL-C goal for secondary prevention of CAD remains unclear. Besides reducing LDL-C, statins also have pleiotropic effects, such as lowering inflammation and stabilizing atherosclerotic plaques.
Authors and Affiliations
Amber Fatima
Keywords
Related Articles
- EP ID EP558250
- DOI 10.17140/HROJ-4-134
- Views 164
- Downloads 0
Clinical Spectrum of Pediatric Optic Neuritis in Indian Children
Purpose: To study the clinical spectrum of pediatric optic neuritis in Indian children at a tertiary care centre. Methods: A retrospective study of patients diagnosed with optic neuritis below 20 years of age at a tertia...
A Clinical Application of the “Brody Effect”
Brody described the importance of differences in resistivity between blood in the left ventricular lumen and the myocardium, and the distance between the primary dipole in the myocardium and the image dipole in the lumen...
Cardiac Telerehabilitation - Current State and Clinical Perspectives
Cardiovascular Diseases (CVD) are regarded as a leading cause of death globally, constituting important medical, social and economical problem. Systematic reviews and metaanalyses show the positive effect of exercise-bas...
E-Care Project: A Promising E-Platform for Optimizing Management of Chronic Heart Failure and Other Chronic Diseases
Monitoring patients with heart failure by using telemedicine systems is a potential means for optimizing the management of these patients. The E-care project is developing an “intelligent” communicative platform enabling...
Experimental Vein Graft Research: A Critical Appraisal of Models
Experimental models of vein grafting need to have specific relevance to the clinical complications encountered in coronary artery bypass grafting: acute thrombosis, neointima associated stenosis, and progression of late-...