Leu7Pro polymorphism of preproneuropeptide Y during a course of metabolic disease: functional analysis by gene ontology
Journal Title: Journal of Neurological Sciences-Turkish - Year 2007, Vol 24, Issue 3
Abstract
Background and Purpose: Neuropeptide Y (NPY), one of the most abundant neuropeptides found in the central nervous system (CNS), has been implicated in the regulation of many metabolism. Preproneuropeptide Y (PPNPY) is the signal peptide of the NPY. Effect of PPNPY Leu7Pro polymorphism on metabolic disorder is widely discussed and still controversial. Material and methods: To study the functional aberration in the human wild and mutate types of PPNPY in pathogenesis of type 2 diabetes is hard. Here, the author used a new gene ontology technology to predict the molecular function of human wild and mutate types of PPNPY. Results: Here, it can be seen that there is no functional difference between wild and mutate types of PPNPY. The common functions as Receptor binding, G-protein coupled receptor binding, hormone activity, neuropeptide hormone activity, G-protein coupled receptor activity, calcium channel regulator activity can be seen. Conclusion: This can support the null effect of this polymorphism in clinical findings of the patients. Therefore, this polymorphism might not be an important factor and have null effect in metabolic disorder. Finally, the author hereby recommends for a further study to analyze other know genetic variants within PPNPY gene to add more knowledge.
Authors and Affiliations
Viroj WIWANITKIT
Keywords
Related Articles
- EP ID EP112930
- DOI -
- Views 59
- Downloads 0
Biochemical Changes in The Intervertebral Discs After Electromagnetic Radiation: An Experimental Study
Objective: We investigated the intervertebral discs in a rat electromagnetic radiation (EMR) model to demonstrate that electromagnetic radiation is a cause of degenerative intervertebral discs. Methods: Rats were random...
Cerebral İntratumoral Haemorrhage Associated With Neurofibromatosis Type 1 Case Report
Patients with Neurofibromatosis type 1 usually present themselves with multiple neurofibromas and cafe-au-lait spots. Vascular disorders have been reported in only a small number of cases. The patient was a 34 year-old w...
Neurological Problems in Rural Areas Affected By The Fukushima Accident: A Topic For Discussion
Demansta Görsel Sanatlar
Bu derlemede, Alzheimer Hastalığı (AH), Lewy cisimcikli demans (LCD) ve frontotemporal demans gibi üç temel demans tipinde özellikle görsel sanatlardaki örnekler tartışılmıştır. Demanslarda kognitif kayıplara karşın, yen...
Intra-Extracranial Meningioma
Extracranial extension of intracranial meningiomas are seen rarely. Number of such cases have decreased due to early diagnosis of intracranial meningiomas with modern radiological techniques. Surgical treatment is diffic...