Leucine: green and efficient catalyst for the synthesis of 4H-chromenes
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 10, Issue 9
Abstract
Leucine, a naturally occurring α-amino acid, has been found as an effective catalyst to effect the one-pot three-component condensation reaction between aromatic aldehydes, malononitrile and 5,5-dimethyl-1,3-cyclohexanedione (dimedone). Various 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives are conveniently prepared by these reactions in excellent yields. High yields, short reaction times, simple work-up, use of green and naturally occurring catalyst and solvent are the main merits of the present protocol.
Authors and Affiliations
Davood Azarifar, Younes Abbasi, Omolbanin Badalkhani
Keywords
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- EP ID EP652795
- DOI 10.24297/jac.v10i9.6168
- Views 171
- Downloads 0
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