Leukocytic Response and Spleen Morphology of Albino Rats Exposed to Graded Levels of Lead Acetate
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2010, Vol 3, Issue 4
Abstract
Aim. The study investigated the leukocytic response and spleen morphology of albino rats exposed to graded dose levels of lead acetate. Material and Methods. Four groups of 5 rats received lead acetate treatment per os for 14 days, as follows: group A (0.25 mg/kg body weight), group B (0.50 mg/kg body weight), group C (1.00 mg/ kg body weight) and group D (no lead acetate treatment-control). Thereafter, total leukocyte count (TLC), differential leukocyte count (DLC) and histomorphology of the spleen were assessed. Total leukocyte count, differential leukocyte count and histomorphology of rats that received the lead acetate treatment were compared to control rats. Results. Results have shown that the administration of lead acetate to rats led to a significant (p < 0.05) increase in TLC with an increase in the number of lymphocytes (p < 0.05). The number of absolute monocytes and neutrophils in the lead acetate exposed rats were significantly (p < 0.05) low. The microscopic changes from the spleen sections of the lead acetate treated rats suggest immune alteration and splenic damage. Conclusion. Therefore the study confirms the risk of experiencing immunosuppression for humans and other species that may be exposed to lead.
Authors and Affiliations
Ikechukwu Reginald Obidike| Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria, Wilfred Sunday Ezema| Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria, Lawrence Okonkwo Aka| Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria, Samuel Chukwuneke Udem| Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria, Gladys Chinelo Onah| Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria
Keywords
Related Articles
- EP ID EP8766
- DOI 10.3889/MJMS.1857-5773.2010.0112
- Views 365
- Downloads 20
Antioxidant Effects of Nigella Sativa in the Treatment of Experimentally Induced Rhinosinusitis
Aim. The objective of this study was to investigate the effect of Nigella sativa (NS) in experimental bacterial rhinosinusitis. Material and Methods. Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rab...
Risks and Complications in Aesthetic and Functional Septorhinoplasty
Background: Rhinoseptoplasty (RSP) is regarded to be associated with many risks. The expectations of patient and physician are not always corresponding. Besides of postoperative deformities many other risks and complic...
Understanding the Role of General Dentists in the Process of Screening and Early Diagnosis of Oral Premalignant And Malignant Lesions - Brief Literature Review
Aim: To indicate about the need for involving general dentists in the process of screening and early detection of malignant and premalignant lesions. To make brief literature review, which lesions are included under th...
Comparing Preterm and Term Newborns Serum Adiponectin and Leptin Concentrations and their Correlations with Anthropometric Parameters
Introduction: Serum adipocytokines concentration, their mutual relationship and correlations with anthropometric data could be indicators of fetal and neonatal growth maturity level in term and preterm infants. Object...
Intestinal Submucosal Lipomas
Background: Gastrointestinal tract is uncommon localization for lipomas, but if present they are 90% submucosal and 10% subserosal. Intestinal submucosal lipomas are the most common benign nonepithelial intestinal tumo...