Level of Some Adipokines in Obese Type 2 Diabetic Egyptian Patients with Coronary Artery Stenosis
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 1, Issue 3
Abstract
Cardiovascular diseases (CVD) are the leading global cause of death accounting for 17.5 million deaths per year, a number that is expected to grow to more than 23.6 million by 2030. Cardiovascular diseases result mainly from atherosclerosis which involves a chronic and progressive inflammatory response of the vessel wall to injuries promoted by risk factors such as hypertension, dyslipidemia, diabetes and others. Type 2 diabetes mellitus (T2DM) is usually proceeded with a state of insulin resistance or insufficient insulin signal pathways that plays a crucial role in the pathogenesis of the disease and its associated complication. Obesity is a chronic serious and growing problem of excessive body fat which has been linked with dyslipidaemia, CVD and diabetes. Besides, white adipose tissue (WAT) is recognized as an important player in obesity-mediated and CVD. It is well established that WAT is an active endocrine organ that contributes to the inflammatory process in obese subjects and secretes a variety of adipokines. These adipokines including chemerin, vaspin, omentin-1 and apelin affect the whole-body homeostasis by influencing numerous physiological and biological processes and fulfilling their actions via different signaling pathways and chemical mediators. According to the latest WHO data published in 2014, CVD and T2DM deaths in Egypt reached 23.14% and 1.55%, respectively of total deaths. Furthermore, it is estimated that 70% of Egypt’s adult population suffers from obesity, a statistic that places it as the 7th most obese country worldwide.
Authors and Affiliations
Rania Farag A El Telbany
Keywords
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- EP ID EP598621
- DOI 10.32474/AOICS.2018.01.000111
- Views 86
- Downloads 0
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