Levels of Insulin, IL-6 and CRP in Patients with Unstable Angina
Journal Title: Advances in Clinical and Experimental Medicine - Year 2013, Vol 22, Issue 5
Abstract
<strong>Background. </strong>Unstable angina is a condition in which your heart doesn’t get enough blood flow and oxygen. It may lead to a heart attack. Insulin resistance is typically defined as decreased sensitivity or responsiveness to metabolic actions of insulin, such as insulin-mediated glucose disposal in skeletal muscle and adipose tissue and inhibition of hepatic glucose production<em>. </em>Crosstalk between inflammatory signaling pathways and insulin signaling pathways causes metabolic insulin resistance and endothelial dysfunction.<br /><strong>Objectives. </strong>The present study aimed to evaluate the serum levels of pro-inflammatory cytokines and insulin in unstable angina patients.<br /><strong>Material and Methods. </strong>The study included 50 patients with unstable angina divided into a female group which contained 16 female patients with an age range of 35–73 years, and a male group which contained 34 male patients with an age range of 40–72 years. Control groups contained forty healthy individuals divided into a female group which contained 16 healthy females with an age range of 35–73 years, and a male group which contained 24 males with an age range of 42–72 years. ELISA kits were used to measure insulin, IL-6 and CRP. The kits were imported from Biological Company in the United States of America.<br /><strong>Result. </strong>The levels of insulin and IL-6 were considerably elevated throughout (p < 0.001), an optimistic relationship concerning insulin with CRP and IL-6 in unstable angina patients.<br /><strong>Conclusions. </strong>There was increase in the level of insulin regarding patients with unsteady angina as a result of insulin resistance that was caused by the elevated level of proinflammatory cytokine (IL-6).
Authors and Affiliations
Isam Al-Karkhi, Ammal Ibrahim, Abeer Yaseen
Keywords
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