LEVELS OF S. LIPASE AND S. AMYLASE IN ASSESSING SEVERITY AND CAUSE OF ACUTE PANCREATITIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 11
Abstract
BACKGROUND Alcoholic acute pancreatitis may present with a wide spectrum of symptoms ranging from mild chronic abdominal discomfort to a presentation that of an acute abdomen. Diagnosing it sometimes becomes a challenge to physician. Objectives- To investigate the role of Serum Lipase to Serum Amylase ratio in differentiating alcoholic cause of acute pancreatitis from non-alcoholic acute pancreatitis, and whether levels can be correlated with CT abdomen severity score. MATERIALS AND METHODS A total of 55 patients of acute pancreatitis (AP) were admitted in Medicine Department from January 2015 to August 2016, of which 47 patients were included in the study. S. amylase and S. lipase were measured in first 48 hours simultaneously after admission and thus calculating the L/A ratio. CECT abdomen was done in 3 - 5 days after admission and grading was done by Balthazar criteria. RESULTS Among these, the lipase/ amylase ratio in alcoholic AP ranged from was significantly higher than non-alcoholic AP (mean L/A ratio in alcoholic AP was 4.03 ± 1.44; and non-alcoholic AP was 2.27 ± 0.85 with p= 0.0001), but L/A ratio was unable to distinguish between various degrees of severity in the acute pancreatitis. CONCLUSION S. lipase/ S. amylase ratio could help in differentiating the alcoholic and non-alcoholic cause of acute pancreatitis, but it does not correlate with the CT score severity of acute pancreatitis.
Authors and Affiliations
Jitendra Singh Kushwaha, Shri Krishna Gautam, Nagendra Pratap Verma, Harshit Khare, Brijesh Kumar, Reena Singh
Keywords
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- EP ID EP411618
- DOI 10.14260/jemds/2018/309
- Views 67
- Downloads 0
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