Levetiracetam-Induced Hypokalemia and Hypomagnesemia
Journal Title: Scholars Journal of Medical Case Reports - Year 2018, Vol 6, Issue 1
Abstract
Abstract: Levetiracetam is an antiepileptic drug commonly used in focal and generalized epileptic seizures because it has a low side-effect profile. However, recent studies in the literature have reported unexpected side effects thought to be associated with levetiracetam. In this report, we present the case of a patient with hypokalemia and hypomagnesaemia that are thought to be associated with the use of levetiracetam. A 34-year-old female patient was brought to the emergency department because she jumped from the fourth floor of a building, attempting to commit suicide. The laboratory investigation detected hypopotassemia and hypomagnesaemia. A detailed examination revealed no additional pathology that may have caused electrolyte imbalance. The patient had been taking levetiracetam at a dose of 2500 mg/day because of a history of epilepsy. Considering that the electrolyte imbalance in the patient may have been associated with the use of levetiracetam, the drug was tapered off, and treatment with 100 mg/day lamotrigine was initiated. The patient’s electrolyte imbalance improved during the follow-up period. This case reveals that increasingly used new antiepileptic drugs may have unforeseen side effects and thus require meticulous monitoring.
Authors and Affiliations
Mustafa Demir, Omer Canpolat, Irem Pembegul Yigit, Ayhan Dogukan
Keywords
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